The Hill cipher algorithm is one of the symmetric key algorithms that have many variations but still not suited for all zeroes plaintext block. Chosen-plaintext attack can be possible on Toorani and Falahati Hill Cipher Algorithm by two closely related variants of Hill Cipher. In this paper we have presented a new approach of Hill Cipher (RDHili Cipher) using DNA cryptography and TFHiII Cipher to overcome the drawbacks of TFHili. We implement this algorithm for image encryption in which firstly the image will be converted into binary value and the nibble of binary value will be rotated, then it will be converted into DNA, and then DNA to Amino Acids. Secondly TFHiII Cipher can be applied on Amino Acids.The output is measured for the security level based on Correlation, histogram and entropy. The experimental results showed that the combination technique resulted in a higher entropy value and lower correlation, and a more uniform histogram, compared to the Hill Cipher, affine Hill, TFHiII and SVK Hill Cipher. This implies the good quality of the retrieved image compared to the original one.