Sedation of children for auditory brainstem response using ketamine-midazolam-atropine combination – a retrospective analysis

Bocskai, Tímea; Németh, Á.; Bogár, Lajos; Pytel, József

doi:10.1186/2193-1801-2-178

Cited by 12 publications

(10 citation statements)

References 21 publications

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“…23,27,28 It also enhances the benefit of the prophylactic coadministration of atropine (anticholinergic) as an adjunct in sedation with ketamine. it is in accordance with the findings of other studies which reported that it reduces the hypersalivation, excessive secretions of the respiratory tract, and nausea and vomiting, 29,30 which are the most common complications with ketamine. 5,31…”

Section: Discussionsupporting

confidence: 93%

Two oral sedation regimens in pediatric dentistry: a randomized controlled trial

Hammadyeh

Altinawi

Rostom

2020

APIC

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Objectives: Dental procedures are always associated with some degree of anxiety, and children are usually more prone to it. General anesthesia may have to be used in more complex procedures, but many dental procedures can successfully be undertaken with therapeutic sedation. The aim of this trial was to evaluate the effectiveness of oral sedation using dexmedetomidine in comparison with ketamine in the management of uncooperative pediatric patients during dental treatment. Methodology: A randomized clinical trial was carried out on 40 ASA physical status-I children aged 2-6 y to investigate the effect of using dexmedetomidine and ketamine with atropine for sedation. The children were equally and randomly divided into two groups: Group K: received oral ketamine 5 mg/kg with atropine 0.01 mg/kg, and Group D: received oral dexmedetomidine 3 µg/kg. Recovery time, vital signs, and side effects were all recorded. Behavior rating was also assessed using the Ohio State University Behavioral Rating Scale (OSUBRS). Results: The children in Group D were more sedated than in Group K, but the difference was not statistically significant (p = 0.22). The median recovery time was significantly shorter in Group D than in Group K (p = 0.003). No adverse effects, episodes of respiratory or cardiovascular instability were noted in either groups. Conclusions: Oral dexmedetomidine is equally effective to oral ketamine for sedation in children undergoing outpatient dental procedures, but has relatively a shorter recovery time. Citation: Hammadyeh A, Altinawi M, Rostom F. Two oral sedation regimens in pediatric dentistry: a randomized controlled trial. Anaesth pain & intensive care 2019;23(4)__

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Section: Discussionsupporting

confidence: 93%

Two oral sedation regimens in pediatric dentistry: a randomized controlled trial

Hammadyeh

Altinawi

Rostom

2020

APIC

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“…Depending on the type and purpose of analysis, a non-cooperating patient may be treated with a pharmacological therapy based on sedatives, anesthetics, or a combination of the two [12] . The sedative agent generally used in the ABR survey is chloral hydrate, probably because it was the first molecule to be used [13] .…”

Section: Objectivementioning

confidence: 99%

Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Volpe¹,

Lucia²,

Pirozzi³

et al. 2017

Int Adv Otol

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MATERIALS and METHODS:In total, 748 children aged between 12 and 48 months were included in the study and divided into three groups: A: placebo (n=235), B: melatonin (n=246), and C: melatonin, tryptophan, and vitamin B6 (n=267). RESULTS:In groups B and C, in addition to physiological awakening, we observed a significant reduction in the number of repeated analyses as well as drug regimen usage. CONCLUSION:This study confirms the strategic role of melatonin as an inducer of spontaneous sleep. However, above all, it suggests that the administration of a solution containing melatonin, tryptophan, and vitamin B6 significantly reduces the number of repeated ABR examinations as well as the percentage of repeated analysis performed using sedative drugs compared to both the control group and the melatonin-only group.

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“…26 It also confirms the benefit of the prophylactic coad ministration of atropine (an anticholinergic) as an adjunct to intravenous ketamine sedation in children. This is con sistent with many studies, which have reported that atro pine counters the effects of some sedatives, like ketamine, and reduces hypersalivation, excessive secretion from the respiratory tract, nausea, and vomiting, [27][28][29] which are the most common complications related to the use of keta mine. 6,7,30…”

Section: Orcid Idsmentioning

confidence: 59%

Comparison of two intravenous sedation techniques for use in pediatric dentistry: A randomized controlled trial

2019

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Background. Psychological methods are the preferred behavior management techniques (BMTs) for children in the dental clinical set. However, sometimes they are not successful. On such occasions, pharmacological methods can be good alternatives. Intravenous sedation is one of these methods, which are very useful in behavior management. It is highly effective when applied appropriately.Objectives. The aim of this study was to evaluate the efficacy of intravenous sedation using dexmedetomidine in comparison with ketamine and atropine in uncooperative children during dental treatment.Material and methods. The study was performed on 40 healthy uncooperative children aged 2-6 years. They were equally and randomly divided into 2 groups: group D -intravenous dexmedetomidine with a loading dose of 1 µg/kg body weight (b.w.), which was followed by 0.2 µg/kg b.w./h via continuous infusion; and group K -intravenous ketamine 2 mg/kg b.w. with atropine 0.01 mg/kg b.w. Vital signs, recovery time and adverse effects were all recorded. Behavior was also evaluated using the Ohio State University Behavioral Rating Scale (OSUBRS).Results. Statistically significant differences appeared in the degree of behavior between the 2 groups (p = 0.03). Group D did better than group K. The mean recovery time was shorter in group D than in group K, but there were no statistically significant differences (p = 0.12). No side effects, episodes of cardiovascular or respiratory instability were reported in either group.Conclusions. The use of intravenous sedation in managing uncooperative children is more effective with dexmedetomidine than with ketamine. The addition of atropine as an adjunct to intravenous ketamine sedation helps in preventing complications. Cite asHammadyeh AR, Altinawi MK, Rostom F. Comparison of two intravenous sedation techniques for use in pediatric dentistry: A randomized controlled trial. Dent Med Probl.

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Sedation of children for auditory brainstem response using ketamine-midazolam-atropine combination – a retrospective analysis

Cited by 12 publications

References 21 publications

Two oral sedation regimens in pediatric dentistry: a randomized controlled trial

Two oral sedation regimens in pediatric dentistry: a randomized controlled trial

Comparative Study between the use of Melatonin and A Solution with Melatonin, Tryptophan, and Vitamin B6 as an Inducer of Spontaneous Sleep in Children During an Auditory Response Test: An Alternative to Commonly Used Sedative Drugs

Comparison of two intravenous sedation techniques for use in pediatric dentistry: A randomized controlled trial

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