1996
DOI: 10.1164/ajrccm.153.3.8630539
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Sedation of critically ill patients during mechanical ventilation. A comparison of propofol and midazolam.

Abstract: Propofol (P) and midazolam (M) are frequently given by continuous infusion for sedation in critically ill, mechanically ventilated patients. We compared these drugs with regard to: (1) time-to-awaken; (2) reproducibility of bedside assessments of level of sedation; (3) time-to-sedation; and (4) change in oxygen consumption (V O2) from awake to sedated state. Seventy-three patients were prospectively randomized to receive either P (n=37) or M (n=36). Wake-up times after stopping the drug were assessed by blinde… Show more

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Cited by 151 publications
(63 citation statements)
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“…Continuous infusion of midazolam, compared with continuous infusion of propofol or lorazepam, lengthens time until the patient is awake and extubated after sedation has been stopped [193][194][195]. In critically ill patients, the midazolam half-life and volume of distribution are increased [196].…”
Section: Sedation and Paralysismentioning
confidence: 99%
“…Continuous infusion of midazolam, compared with continuous infusion of propofol or lorazepam, lengthens time until the patient is awake and extubated after sedation has been stopped [193][194][195]. In critically ill patients, the midazolam half-life and volume of distribution are increased [196].…”
Section: Sedation and Paralysismentioning
confidence: 99%
“…Kress and colleagues 8 introduced the concept of DIS in 1996. They conducted a trial in which 73 patients were randomized to receive a continuous infusion of propofol or midazolam.…”
Section: Daily Interruption Of Sedationmentioning
confidence: 99%
“…Seul le propofol inhibait la production d'IL-2 et stimulait la production d'IFN-γ. Kress et al [56] ont comparé le propofol et le midazolam dans une étude randomisée portant sur 73 patients. Le groupe propofol présentait des temps de réveil à l'arrêt de la perfusion de l'agent sédatif significativement plus rapides, avec une plus forte probabilité d'un réveil en moins de 60 minutes.…”
Section: Agents Hypnotiquesunclassified