Sedation of the Critically Ill Patient

Anaesthetic and Cardiopulmonary Effects of Dexamedetomidine, Buprenorphine, Dexmedetomidine – Buprenorphine on Alfaxalone in Adult Rabbits – A comparative Study

“…The administration of Dexdomitor ® and combination of Dexdomitor ® and buprenorphine protocol may be useful for non-painful procedures requiring extended immobility. It also agrees with the findings of Perkowski [21] who also stated that the combinations of opioids (buprenorphine) and alpha2-adrenoceptor agonists (Dexdomitor ® ) can lead to supra-additive or synergic antinociceptive and sedative effects in the canine species.…”

“…These effects are a safety concern during anaesthesia. Dexdomitor ® -Buprenorphine-Alfaxan ® combination produced significant reduction in heart rate and this agrees with the findings by Perkowski [21] who reported that Dexdomitor ® in combination with any of the opioids would result in cardiovascular depression, compared with results for administration of Dexdomitor ® alone. Besides, buprenorphine, a mu opioid receptor agonist, also produces bradycardia [18].…”

“…The combination of Dexdomitor ® and Alfaxan ® produced more ventilatory depression, determined by marked decrease in SpO 2 . Significant increase in the respiratory rate was observed in the Dexdomitor ® -buprenorphine-Alfaxan ® treatment group as opposed to the cardiopulmonary depression observed with this combination as reported by Perkowski [21].…”