Sedative effects of an intramuscular or intranasal combination of sufentanil and midazolam in New Zealand White rabbits

Freitag, Flávio Augusto Vieira; Ferreira, Ariele Aparecida; Teixeira, William Timboni; Kerr, Carolyn L.; Duque, Juan Carlos

doi:10.1016/j.vaa.2022.04.006

Cited by 2 publications

(5 citation statements)

References 7 publications

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“…This divergence from our study could be explained by the sternal position used by Yanmaz et al [ 24 ], which could have positively influenced the absorption of the mixture. Similarly, IND of a mix of midazolam and sufentanil resulted in a faster LRR compared to IM administration in eleven rabbits in another study [ 23 ]. Times to LRR in our study are comparable to those reported for the same mixture administered IM, at slightly different dosages [ 4 ].…”

Section: Discussionmentioning

confidence: 99%

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Intranasal Atomization of Ketamine, Medetomidine and Butorphanol in Pet Rabbits Using a Mucosal Atomization Device

Degerfeld

Serpieri

Bonaffini

et al. 2023

Animals

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A non-invasive method of drug delivery, intranasal atomization, has shown positive results in human medicine and in some animal species. The objective of this study was to evaluate the effects of intranasal atomization, compared to intramuscular administration, of a mix of anesthetic drugs in pet rabbits. In total, 104 mixed-breed pet rabbits, undergoing various types of surgery, received a combination of ketamine, medetomidine, and butorphanol (20, 0.4, and 0.2 mg/kg) by intranasal atomization using a Mucosal Atomization Device (Group MAD) or intramuscular administration (Group IM). When required, isoflurane was dispensed through a face mask. At the end of the procedures, atipamezole was administered using the same routes in the respective Groups. There were no differences in time to loss of righting reflex between the groups, while differences were found for the need for isoflurane (higher in Group MAD) and recovery time, occurring earlier in Group MAD. The results suggest that intranasal atomization of a combination of ketamine, medetomidine, and butorphanol produces a lighter depth of anesthesia in pet rabbits, compared to intramuscular administration. Intranasal atomization can be performed to administer sedative and anesthetic drugs, avoiding the algic stimulus related to the intramuscular inoculation of drugs.

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Section: Discussionmentioning

confidence: 99%

“…In veterinary medicine, IND of sedative and anesthetic drugs has been evaluated in several species, including dogs, cats, pigs [ 9 , 18 , 19 ], and rabbits, in which different combinations of drugs were used [ 20 , 21 , 22 , 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Intranasal Atomization of Ketamine, Medetomidine and Butorphanol in Pet Rabbits Using a Mucosal Atomization Device

Degerfeld

Serpieri

Bonaffini

et al. 2023

Animals

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show abstract

“…1,2 Unfortunately, anaesthesiarelated mortality in rabbits is higher than in cats and dogs because of excitement and extreme cardiovascular stimulation before the anaesthetic administration. 3,4 Therefore, many anaesthetic drugs and routes of administration have been investigated to reduce potentially anaesthesia-related mortality in rabbits. 1,4 Intranasal (IN) administration in human paediatric patients has become increasingly popular because of the efficiency of administration, rapid onset of action, noninvasiveness and relative painlessness to the patient.…”

Section: Introductionmentioning

confidence: 99%

“…After dogs and cats, rabbits are the most common companion animal species presented for anaesthesia in clinical practice 1,2 . Unfortunately, anaesthesia‐related mortality in rabbits is higher than in cats and dogs because of excitement and extreme cardiovascular stimulation before the anaesthetic administration 3,4 . Therefore, many anaesthetic drugs and routes of administration have been investigated to reduce potentially anaesthesia‐related mortality in rabbits 1,4 …”

Section: Introductionmentioning

confidence: 99%

“…3,4 Therefore, many anaesthetic drugs and routes of administration have been investigated to reduce potentially anaesthesia-related mortality in rabbits. 1,4 Intranasal (IN) administration in human paediatric patients has become increasingly popular because of the efficiency of administration, rapid onset of action, noninvasiveness and relative painlessness to the patient. 5 Additionally, IN administration has been recommended as an alternative to conventional routes of drug administration in rabbits due to it requiring less training to perform correctly.…”

Section: Introductionmentioning

confidence: 99%

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Sedative and cardiopulmonary effects of intranasal butorphanol with midazolam or dexmedetomidine in New Zealand white rabbits

et al. 2023

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Background: This study aimed to compare the sedative and cardiopulmonary effects of intranasal (IN) administration of dexmedetomidine-butorphanol (DB) and midazolam-butorphanol (MB) combinations in New Zealand white rabbits. Methods: Eight New Zealand white rabbits were sedated by IN administration of a combination of 0.1 mg/kg dexmedetomidine and 0.4 mg/kg butorphanol (DB treatment) and 2 mg/kg midazolam and 0.4 mg/kg butorphanol (MB treatment). The electrocardiogram, pulse rate (PR), respiratory frequency (f R ), arterial haemoglobin oxygen saturation (SpO 2 ), fraction of expired carbon dioxide (EtCO 2 ), rectal temperature (RT), noninvasive mean arterial pressure (MAP), noninvasive systolic arterial pressure (SAP) and diastolic arterial pressure (DAP) were recorded. The onset of sedation, duration of sedation and sedation score (SS) were also noted. Results: There were no significant differences in the EtCO 2 , RT, MAP, SAP and DAP measurements between treatments. The PR significantly decreased in DB compared with MB over time (p = 0.001). Compared with baseline, SpO 2 decreased over time in both treatments. The SS was significantly elevated over time in DB compared with MB (p = 0.002). Limitations: No pharmacokinetic information was available for either treatment, so the findings should be interpreted cautiously. Conclusions: IN DB provides more effective sedation than MB, but cardiopulmonary impairment was observed in both treatments.

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Sedative effects of an intramuscular or intranasal combination of sufentanil and midazolam in New Zealand White rabbits

Cited by 2 publications

References 7 publications

Intranasal Atomization of Ketamine, Medetomidine and Butorphanol in Pet Rabbits Using a Mucosal Atomization Device

Intranasal Atomization of Ketamine, Medetomidine and Butorphanol in Pet Rabbits Using a Mucosal Atomization Device

Sedative and cardiopulmonary effects of intranasal butorphanol with midazolam or dexmedetomidine in New Zealand white rabbits

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