Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice

Dougnon, Godfried; Ito, Michiho

doi:10.1007/s11418-019-01358-9

Cited by 35 publications

(29 citation statements)

References 39 publications

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“…Caryophyllene oxide was administered to the mice at the same concentrations as COEO. Benzylacetone was used as positive control [24,27], and as shown in Figure 4, it significantly decreased locomotor activity (p = 0.04), thus validating the experimental model. In the present study, caryophyllene oxide significantly decreased locomotor activity at 0.0004 and 0.04 mg/cage by 56% and 57%, respectively, compared to the control group (F [7,36] = 2.436; p = 0.04) (Figure 4).…”

Section: Caryophyllene Oxide Induced Sedative Activity In Micesupporting

confidence: 60%

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Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

Dougnon

Ito

2021

Pharmaceuticals

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Chromolaena odorata (L.) R.M.King & H.Rob. essential oil (COEO) was investigated for its sedative activity in mice. The results showed that COEO significantly reduced mice locomotor activity and the most efficient concentrations were 0.04 and 0.00004 mg/cage (volume of the cage 61.2L). Analysis of chemical composition of the oil indicated that caryophyllene oxide (43.75%) was the major compound and bioactivity-guided fractionation of the oil was performed to isolate the compound responsible for activity. The data clearly identified sesquiterpene caryophyllene oxide as the compound inducing COEO sedative activity and it was effective in decreasing mice locomotor activity by 56% and 57% at 0.0004 and 0.04 mg/cage, respectively. In order to understand the action mechanisms, caryophyllene oxide was tested for its effects on the central nervous system (CNS) by using a caffeine pre-excited mice test and a pentobarbital sleeping-induced test in mice. The results showed that caryophyllene oxide is a potent CNS depressant. Nevertheless, it fails to potentiate the effects of pentobarbital on the GABAergic system, nor did flumazenil, a GABAA receptor antagonist, reversed its effects. It was especially interesting to note that β-caryophyllene, the precursor of caryophyllene oxide, demonstrated a similar pattern of sedative activity, and the present work further extends actual knowledge on these naturally occurring sesquiterpenes. The findings in this study reveal the new activity of caryophyllene oxide as an innovative way to manage sleep and CNS-related disorders, and demonstrates a satisfactory effect of two interesting sesquiterpene compounds on the CNS.

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Section: Caryophyllene Oxide Induced Sedative Activity In Micesupporting

confidence: 60%

“…In regard to our previous experiments [ 24 , 25 , 26 ], mice were administered different inhalation concentrations of COEO (0.000004, 0.00004, 0.0004, 0.004, 0.04, or 0.4 mg/cage; volume of the cage 61.2 L). Lavender oil was used as positive control and triethyl citrate (TEC) as a negative control.…”

Section: Resultsmentioning

confidence: 99%

Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

Dougnon

Ito

2021

Pharmaceuticals

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“…The major compounds reported were sesquiterpenes, such as (E)-β-caryophyllene, α-humulene, davanone, and germacrene D [15,[21][22][23]. Some monoterpenes were also found in high proportions, such as thymol, sabinene, and limonene [24][25][26].…”

Section: Introductionmentioning

confidence: 99%

Composition, Seasonal Variation, and Biological Activities of Lantana camara Essential Oils from Côte d’Ivoire

et al. 2020

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This work aims to study the variations in the composition of Lantana camara leaf, flower, and stem essential oils over two years. L. camara organs were harvested in Bregbo (East Côte d’Ivoire) each month from June 2015 to June 2017. The essential oils were obtained by hydrodistillation and characterized by GC-MS and 13C NMR. Eighty-four compounds accounting for 84.4–99.1% of the essential oils have been identified. The essential oils hydrodistillated from L. camara are dominated by sesquiterpenes such as (E)-β-caryophyllene and α-humulene, which were found in all samples. Some monoterpenes such as thymol, sabinene, and α-pinene were also present. Statistical analysis (principal component analysis and clustering) revealed a high variability in essential oil composition between the different organs and also within the studied periods, as the thymol proportion was higher during flowering and fruiting months. In addition, the stem, flower, and fruit essential oils were more concentrated in thymol than the leaf essential oils. The proportions of (E)-β-caryophyllene and α-humulene were strictly inverted with the thymol proportion throughout the harvest period or vegetative cycle. The antioxidant, anti-inflammatory and insecticidal activities of leaves and flowers essential oils were also studied. Results showed that L. camara leaf and flower essential oils displayed high antioxidant, anti-inflammatory and insecticidal activities.

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“…Lantana camara has several subspecies and numerous ornamental cultivars [71,72] and as such, the volatile phytochemistry has shown wide variation [65] . In order to place the volatile phytochemistry of the specimens from Vietnam into perspective, a hierarchical cluster analysis (HCA) was carried out comparing the major (37) essential oil components of 60 essential oil compositions reported in the literature [65,66,73–117] along with the four specimens from Vietnam ( Figure 1). The cluster analysis reveals five clusters and one outlier.…”

Section: Resultsmentioning

confidence: 99%

Lantana camara Essential Oils from Vietnam: Chemical Composition, Molluscicidal, and Mosquito Larvicidal Activity

Hùng

Đài

Satyal

et al. 2021

Chemistry & Biodiversity

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Lantana camara is a troublesome invasive plant introduced to many tropical regions, including Southeast Asia. However, the plant does hold promise as a source of essential oils that may be explored for potential use. Fresh water snails such as Pomacea canaliculata, Gyraulus convexiusculus, and Tarebia granifera can be problematic agricultural pests as well as hosts for parasitic worms. Aedes and Culex mosquitoes are notorious vectors of numerous viral pathogens. Control of these vectors is of utmost importance. In this work, the essential oil compositions, molluscicidal, and mosquito larvicidal activities of four collections of L. camara from north‐central Vietnam have been investigated. The sesquiterpene‐rich L. camara essential oils showed wide variation in their compositions, not only compared to essential oils from other geographical locations (at least six possible chemotypes), but also between the four samples from Vietnam. L. camara essential oils showed molluscicidal activities comparable to the positive control, tea saponin, as well as other botanical agents. The median lethal concentrations (LC50) against the snails were 23.6–40.2 μg/mL (P. canaliculata), 7.9–29.6 μg/mL (G. convexiusculus), and 15.0–29.6 μg/mL (T. granifera). The essential oils showed good mosquito larvicidal activities with 24‐h LC50 values of 15.1–29.0 μg/mL, 26.4–53.8 μg/mL, and 20.8–59.3 μg/mL against Ae. aegypti, Ae. albopictus, and Cx. quinquefasciatus, respectively. The essential oils were more toxic to snails and mosquito larvae than they were to the non‐target water bug, Diplonychus rusticus (24‐h LC50=103.7–162.5 μg/mL). Sesquiterpene components of the essential oils may be acting as acetylcholinesterase (AChE) inhibitors. These results suggest that the invasive plant, L. camara, may be a renewable botanical pesticidal agent.

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Sedative effects of the essential oil from the leaves of Lantana camara occurring in the Republic of Benin via inhalation in mice

Cited by 35 publications

References 39 publications

Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

Essential Oil from the Leaves of Chromolaena odorata, and Sesquiterpene Caryophyllene Oxide Induce Sedative Activity in Mice

Composition, Seasonal Variation, and Biological Activities of Lantana camara Essential Oils from Côte d’Ivoire

Lantana camara Essential Oils from Vietnam: Chemical Composition, Molluscicidal, and Mosquito Larvicidal Activity

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