Sedentary behaviour and risk of mortality from all-causes and cardiometabolic diseases in adults: evidence from the HUNT3 population cohort

Chau, Josephine Y.; Grunseit, Anne; Midthjell, Kristian; Holmen, Jostein; Holmen, Turid Lingaas; Bauman, Adrian; Ploeg, Hidde P. van der

doi:10.1136/bjsports-2012-091974

Cited by 143 publications

(134 citation statements)

References 34 publications

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“…The acipimox was reported to reduce triglyceride and cholesterol levels with comparable outcomes as its parent drug, nicotinic acid [94]. In 2003, it was elucidated that acifran (1) is able to bind with both GPR109A and GPR109B receptors, while acipimox (2) is only able to bind with the GPR109A [63]. The binding of nicotinic acid receptors and their ligands results in the antilipolytic effect.…”

Section: Drug Acting On Nicotinic Acid Receptormentioning

confidence: 97%

“…It was noted that GPR109A activation is required for antilipolytic activity. Thus, the structural feature of GPR109A as well as its binding with nicotinic acid Recently in 2010, 2-(trifluoromethyl)pyrido [2,3] pyrimidin-4(3)-one (3) possessing fused pyridine and pyrimidinone rings as a core structure was docked onto the human GPR109A receptor. The molecular docking result showed that nitrogen atoms in both pyridine and pyrimidinone rings interact with positively charged residue of arginine 111 in TMH3 of GPR109A as well as using the carbonyl group of pyrimidinone binds to hydroxyl group of serine 178 of ECL2 through hydrogen bonding [96].…”

Section: Drug Acting On Nicotinic Acid Receptormentioning

confidence: 97%

“…So far, the issue of human being wellness is still of prime importance. In this era of globalization, changing behavior, such as consuming high fat diet, smoking, drinking alcohol, and lacking of exercise, leads to increase risks of many diseases, especially, cardiovascular disease [1][2][3].…”

Section: Introductionmentioning

confidence: 99%

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Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications

Sinthupoom

Prachayasittikul

et al. 2014

Eur Food Res Technol

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Section: Drug Acting On Nicotinic Acid Receptormentioning

confidence: 97%

Section: Drug Acting On Nicotinic Acid Receptormentioning

confidence: 97%

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Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications

Sinthupoom

Prachayasittikul

et al. 2014

Eur Food Res Technol

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“…[9][10][11][12] Investigators have shown that prolonged smartphone usage affects cervical and lumbar spine posture. 13,14 Additional studies have demonstrated that postural alignment affects muscle activity around the spine.…”

Section: Introductionmentioning

confidence: 99%

The reliability and validity of the Saliba Postural Classification System

Collins

Johnson²,

Godwin

et al. 2016

Journal of Manual & Manipulative Therapy

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Objectives: To determine the reliability and validity of the Saliba Postural Classification System (SPCS). Methods: Two physical therapists classified pictures of 100 volunteer participants standing in their habitual posture for inter and intra-tester reliability. For validity, 54 participants stood on a force plate in a habitual and a corrected posture, while a vertical force was applied through the shoulders until the clinician felt a postural give. Data were extracted at the time the give was felt and at a time in the corrected posture that matched the peak vertical ground reaction force (VGRF) in the habitual posture. Results: Inter-tester reliability demonstrated 75% agreement with a Kappa = 0.64 (95% CI = 0.524-0.756, SE = 0.059). Intra-tester reliability demonstrated 87% agreement with a Kappa = 0.8, (95% CI = 0.702-0.898, SE = 0.05) and 80% agreement with a Kappa = 0.706, (95% CI = 0.594-0818, SE = 0.057). The examiner applied a significantly higher (p < 0.001) peak vertical force in the corrected posture prior to a postural give when compared to the habitual posture. Within the corrected posture, the %VGRF was higher when the test was ongoing vs. when a postural give was felt (p < 0.001). The %VGRF was not different between the two postures when comparing the peaks (p = 0.214). Discussion: The SPCS has substantial agreement for inter-and intra-tester reliability and is largely a valid postural classification system as determined by the larger vertical forces in the corrected postures. Further studies on the correlation between the SPCS and diagnostic classifications are indicated.

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“…Low levels of physical activity 151,152 and high levels of sedentary behaviour 165,166 may contribute to these poor health outcomes and reduced life expectancy 13 .…”

Section: Introductionmentioning

confidence: 99%

Physical activity patterns, attitudes and counselling among adults with mental illness

Fraser¹

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___________________________________________________________________The life expectancy of adults with mental illness is significantly less than that of the general population. This is largely due to poor physical health. Physical activity is consistently recommended for the prevention and management of noncommunicable diseases and also has mental health benefits. The aim of this thesis was to understand and promote physical activity in adults with mental illness, to improve physical health.Study One was a cross-sectional study of inpatients in a private hospital. It assessed the (i) feasibility of self-report and objective measurement of physical activity and sedentary behaviour, (ii) levels of physical activity and sedentary behaviour, and (iii) physical activity attitudes and preferences for contexts and sources of support. 101 participants completed questionnaires on physical activity and sitting time, activity preferences and attitudes, psychological distress and sociodemographic and health variables. 38 also wore an accelerometer for 7 consecutive days.Feasibility of measurement was assessed in terms of participant engagement; selfreported ease/difficulty; extreme self-report data values; and adherence to accelerometer wear time criteria. Findings demonstrated that inpatient adults with mental illness can engage with both questionnaire and accelerometry measurement, that it was more feasible but less acceptable to wear an accelerometer than to complete questionnaires, and that this was not influenced by level of psychological distress.Questionnaire data were used to determine time spent in (i) walking and moderateand vigorous-intensity activity (MVPA), and (ii) domain specific sitting time.Accelerometry was used to determine mean daily time spent in MVPA and sedentary behaviour. Bivariate associations between self-reported MVPA, sedentary behaviour and explanatory variables of gender, age, education, body mass and distress were analysed using regression analyses. Self-report data indicated a median of 32 minutes/day in MVPA and a median of 761 minutes/day in sedentary behaviour.iii Accelerometry data indicated an average of 37 minutes/day in MVPA and 664 minutes/day in sedentary behaviour. Analyses indicated no significant associations between explanatory variables and MVPA or sedentary behaviour.Questionnaire data were used to determine (i) physical activity interest; (ii) reasons to do activity; (iii) general knowledge regarding activity benefits; (iv) preferences for activity type, context and sources of support; and (v) activity barriers. More than three quarters (77%) of participants expressed high interest to do physical activity while in hospital, with the most common reasons being to maintain physical health and improve emotional wellbeing (≥95%). More than 90% of participants agreed physical activity was beneficial for managing psychological wellbeing, heart disease, stress, diabetes and quality of life; but fewer than half agreed that activity had benefits for serious mental illness. Part...

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Sedentary behaviour and risk of mortality from all-causes and cardiometabolic diseases in adults: evidence from the HUNT3 population cohort

Cited by 143 publications

References 34 publications

Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications

Nicotinic acid and derivatives as multifunctional pharmacophores for medical applications

The reliability and validity of the Saliba Postural Classification System

Physical activity patterns, attitudes and counselling among adults with mental illness

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