See no allergen, hear no allergen, speak no allergen!

Abstract

Segmental allergen challenge in allergic patients with asthma reveals a previously unknown role for monocytes in the T helper 2 (T H 2)–dependent inflammatory response, whereas in allergic controls without asthma, allergen unresponsiveness seems to be maintained through epithelial-myeloid cell cross-talk that prevents T H 2 cell activation (see related Research Article by Alladina et al. ).

High-throughput CRISPR technology: a novel horizon for solid organ transplantation

“…The transferrin receptor (TFRC/CD71) was identified as an activator of Th effector functions, including IL10 production, and an inhibitor of Tregs. Furthermore, the pathogenesis of helminth infections and allergic diseases is closely associated with Th2-mediated protective type 2 immune responses ( 181 , 182 ) and Th2-dependent inflammatory responses ( 183 – 185 ). One study conducted a genome-wide CRISPR knockout screen in CD4 + T cells from IL13-reporter mice (Rosa26 Cas9 Il13 tdTomato ) using the Brie mouse CRISPR knockout pooled library.…”