Abstract---A split plot experiment in a randomized complete block design with three replications was used to study the effect of three (small -10g, medium -22g, and large -32g ) seed sizes and four (3cm, 6cm, 9cm and 12cm) sowing depths on the germination and growth of Telfairia occidentalis at Uturu, Abia State, Nigeria. Small and large seeds had significantly the highest and least germination rates respectively. Small seeds gave significantly the highest leaf number plant -1 , leaf area, root length, relative growth rate and leaf,stem and root dry weights. Large seeds had statistically the least result of the above parameters. However, large seeds had the highest (P 0.05) root-shoot ratio and leaf area ratio. Seeds sown at 3cm and 6cm depths germinated faster than seeds sown at 9cm and 12cm depths. Seeds sown at 3cm depths had the highest significant percentage germination, plant heights, root shoot ratio and leaf area. However, seeds sown at 9cm depth gave statistically the highest root lengths, root collar diameter and leaf diameter. In terms of plant biomass, 12cm and 6cm sowing depths gave significantly the highest and least leaf and stem dry weights respectively. The 9cm and 12cm sowing depths had higher (P 0.05) root dry weights than the 3cm and 6cm sowing depths. At the 12 th week of the study 3cm and 12cm gave significantly the highest and least relative growth rates respectively. In terms of seed size and sowing depths treatment interactions, large seeds in all the sowing depths had the highest (P 0.05) root shoot ratios. Small and large seeds in all the sowing depths gave significantly and respectively the highest and least relative growth rates, leaf number, root, stem and leaf dry weights. Small seeds at the various sowing depths also had significantly the highest root lengths and plant heights. This study recommends the use of small seed sizes (10g) and 3cm sowing depth for production of T. occidentalis.