Seeded calcite sonocrystallization

Boels, L.; Wagterveld, R.M.; Mayer, M.J.; Witkamp, Geert‐Jan

doi:10.1016/j.jcrysgro.2010.01.016

Cited by 33 publications

(16 citation statements)

References 34 publications

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“…Ultrasound has been widely reported to influence the primary nucleation process accelerating nucleation kinetics, this is typically expressed in terms of reducing the induction time and MSZW [18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33]. Ultrasound can also increase the rate of secondary nucleation, this is manifested as a reduction on the product crystal size distribution [20,22,24,31,32,[34][35][36][37][38][39][40][41][42][43]. Ultrasound can also influence crystal growth [20,25,26,36,40,[44][45][46] although the effect on crystal growth is not as dramatic as on nucleation and arises largely from enhanced mass transfer [46] and can influence crystal morphology.…”

Section: Introductionmentioning

confidence: 99%

“…These include the formation of local hot spots which arise from the large energy release on the collapse of cavitation bubbles creating highly localised regions of extremely high temperature and pressure [50,51], or due to rapid cooling which follows; shockwaves released from cavitation bubbles [52,53], promoting mass transfer and collisions between crystals and adjacent surfaces [54]. These effects of ultrasound on crystallisation have been demonstrated on pharmaceuticals and commodity chemicals including; lactose [35,39,42,55], alpha-dextrose monohydrate [20], glycine [48], p-aminobenzoic acid [47], adipic acid [28], benzoic acid [31], acetylsalicylic acid [27], protein [19] various food products [30,56,57] and in the crystallisation of inorganic materials such as potassium sulphate [26], potassium dihydrogen phosphate [32] and calcite [34]. Ultrasound has also been utilized in continuous crystallisation [28,[58][59][60].…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

et al. 2017

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Sono-crystallisation has been used to enhance crystalline product quality particularly in terms of purity, particle size and size distribution. In this work, the effect of impurities and ultrasound on crystallisation processes (nucleation temperature, yield) and crystal properties (crystal size distribution determined by Focused Beam Reflectance Measurement (FBRM), crystal habit, filtration rate and impurity content in the crystal product by Liquid Chromatography-Mass Spectroscopy (LC-MS)) were investigated in bulk suspension crystallisation experiments with and without the use of ultrasound. The results demonstrate that ultrasonic intervention has a significant effect on both crystallisation and product crystal properties. It increases the nucleation rate resulting in smaller particles and a narrower Particle Size Distribution (PSD), the yield has been shown to be increase as has the product purity. The effect of ultrasound is to reduce the level acetanilide impurity incorporated during growth from a 2 mol% solution of the selected impurity from 0.85 mol% to 0.35 mol% and likewise ultrasound reduces the uptake of metacetamol from 1.88 mol% to 1.52 mol%.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

et al. 2017

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“…Dalas reported a retardation effect in growth rate of calcium carbonate by 62% at ultrasonic intensity of 80 W/mL [12]. Conversely, Boels et al found that the volumetric crystal growth rate of calcite in seeded sonocrystallization was enhanced by 46% at 42.15 Hz and 17 W/L [15]. Wagterveld et al also found that the occasion of ultrasound application has a different effect on the nucleation of calcium carbonate [1].…”

Section: Contents Lists Available At Sciencedirectmentioning

confidence: 99%

“…There are also a number of alternative non-chemical treatment options available, such as magnetic, electronic and electrolytic device treatment [8][9][10][11]. Among these non-chemical methods, a more economical and green method, ultrasonic treatment received much attention due to its enhancement effect in crystallization processes [12][13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Ultrasonic Crystallization of Calcium Carbonate in Presence of Seawater Ions

Han

et al. 2015

Desalination

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“…In this stage, new crystalline material will be deposited on the surfaces of the priory formed crystals. This deposition preferentially takes place on damaged edges and surfaces, masking possible erosion effects caused by sonofragmentation [5,19,61]. Finally, ultrasound also increases the collision frequency by a direct interaction between shockwaves or liquid jets and the aggregates which will disrupt the latter before an agglomerative bond is formed [25].…”

Section: Ultrasonic Treatment During the Entire Cooling Profilementioning

confidence: 99%

Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient

et al. 2017

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Application of ultrasound during crystallization can efficiently inhibit agglomeration. However, the mechanism is unclear and sonication is usually enabled throughout the entire process, which increases the energy demand. Additionally, improper operation results in significant crystal damage. Therefore, the present work addresses these issues by identifying the stage in which sonication impacts agglomeration without eroding the crystals. This study was performed using a commercially available API that showed a high tendency to agglomerate during seeded crystallization. The crystallization progress was monitored using process analytical tools (PAT), including focus beam reflectance measurements (FBRM) to track to crystal size and number and Fourier transform infrared spectroscopy (FTIR) to quantify the supersaturation level. These tools provided insight in the mechanism by which ultrasound inhibits agglomeration. A combination of improved micromixing, fast crystal formation which accelerates depletion of the supersaturation and a higher collision frequency prevent crystal cementation to occur. The use of ultrasound as a post-treatment can break some of the agglomerates, but resulted in fractured crystals. Alternatively, sonication during the initial seeding stage could assist in generating nuclei and prevent agglomeration, provided that ultrasound was enabled until complete desupersaturation at the seeding temperature. FTIR and FBRM can be used to determine this end point.

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Seeded calcite sonocrystallization

Cited by 33 publications

References 34 publications

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

The Effect of Ultrasound on the Crystallisation of Paracetamol in the Presence of Structurally Similar Impurities

Ultrasonic Crystallization of Calcium Carbonate in Presence of Seawater Ions

Agglomeration Control during Ultrasonic Crystallization of an Active Pharmaceutical Ingredient

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