Seeding of osteosarcoma in the biopsy tract of a patient with multifocal osteosarcoma

Iemsawatdikul, Kriengkrai; Gooding, Charles A.; Twomey, Eilish; Kim, Grace; Goldsby, Robert E.; Cohen, Inbal; O’Donnell, Richard J.

doi:10.1007/s00247-005-1431-9

Cited by 27 publications

(12 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some authors have suggested that complete resection of the percutaneous biopsy tract rarely is achieved [10]. Although resection of the biopsy tract is recommended by numerous authors [5,13,14], neither we nor Oliveira et al [20] could find a study that definitively confirmed the frequency of biopsy tract seeding or that there is increased risk of local recurrence when the biopsy tract is not resected.…”

Section: Introductionmentioning

confidence: 76%

Are Biopsy Tracts a Concern for Seeding and Local Recurrence in Sarcomas?

Barrientos-Ruiz

Ortiz‐Cruz

Serrano-Montilla

et al. 2017

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

Background A biopsy is the final step in the diagnosis of sarcomas. Complete resection of the biopsy tract traditionally has been recommended in musculoskeletal oncology guidelines, as that tract is considered potentially seeded with tumor cells. However, to our knowledge, the frequency and implications of contamination of the biopsy tract-specifically with respect to the likelihood of local recurrence-and the factors that affect cell seeding are not well described. Questions/purposes We asked: (1) How often are biopsy tracts contaminated with pathologically detectable tumor cells at the time of tumor resection? (2) What factors, in particular biopsy type (open versus percutaneous), are associated with tumoral seeding? (3) Is biopsy tract contamination associated with local recurrence? Methods This is a retrospective study of a database with patient data collected from a single center between 2000 and 2013. We treated 221 patients with sarcomas. A total of 27 patients (12%) were excluded and 14 (6%) were lost to followup. One hundred eighty patients finally were included in the analysis who either had biopsies at our center (112) or biopsies at outside institutions (68). Of those performed at our center, 15 (13%) were open and 97 (87%) were percutaneous; of those at outside centers, those numbers were 47 (69%) and 21 (31%) respectively. Median followup was 40 months (range, 24-152 months). During the study period, we generally performed percutaneous biopsies as a standard practice for the diagnosis of bone and soft tissue sarcomas and open biopsies were done when the percutaneous procedure failed to provide a histologic characterization. The mean age of the population was 48 years (range, 7-87 years); 60% were male; 42% had bone sarcomas. Nineteen patients had preoperative radiotherapy and 56 had postoperative radiotherapy. Fifty-seven patients received neoadjuvant chemotherapy and 73 had Each author certifies that he or she has no commercial associations (eg, consultancies, stock ownership, equity interest, patent/licensing arrangements, etc) that might pose a conflict of interest in connection with the submitted article. All ICMJE Conflict of Interest Forms for authors and Clinical Orthopaedics and Related Research 1 editors and board members are on file with the publication and can be viewed on request. Each author certifies that his or her institution has or waived for the human protocol for this investigation and that all investigations were conducted in conformity with ethical and confidentiality principles of research. This work was performed at the Musculoskeletal Tumor Unit, Orthopaedics and Traumatology Department, at La Paz University Hospital, Madrid, Spain. We determined what proportion of biopsy tracts were contaminated by pathologic analysis of the biopsy tract specimen; during the period in question, our routine practice was to excise the biopsy tract whenever possible at the time of the definitive resection. Using the logistic regression test and Mantel-Haenszel test, we compared open wi...

show abstract

Section: Introductionmentioning

confidence: 76%

Are Biopsy Tracts a Concern for Seeding and Local Recurrence in Sarcomas?

Barrientos-Ruiz

Ortiz‐Cruz

Serrano-Montilla

et al. 2017

Clinical Orthopaedics &Amp; Related Research

View full text Add to dashboard Cite

show abstract

“…In an attempt to trace the profile of patients with contamination of the biopsy tract, it is observed that the case reports addressed 10 cases of contamination of the biopsy tract in the musculoskeletal system. For these cases, the age ranged from 7 23 to 74 years old 22 . Eight male patients 16 , 19 - 24 and two female patients 19 have been reported.…”

Section: Discussionmentioning

confidence: 99%

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

et al. 2014

View full text Add to dashboard Cite

To identify, through a systematic literature review, the characteristics of neoplasm seeding in biopsy performed on the musculoskeletal system. We performed a search on PubMed, MEDLINE, LILACS and SciELO from August to October 2010. We included articles that addressed the neoplasm seeding in biopsy performed on the musculoskeletal system. The search was limited to English, Spanish and Portuguese as publication languages, but it was not limited by year of publication. We retrieved 2858 articles, but only seven were selected based on inclusion and exclusion criteria. Other four papers were found in the references of selected articles, totalizing 11 articles that were used to perform this systematic review. Issues may be raised in the literature: age and gender don't seem to influence the occurrence of neoplasm seeding; without resection of the biopsy tract, the possibility of local recurrence is very real; the influence of the type of tumor in the occurrence of neoplasm seeding is uncertain; it is impossible to conclude whether the closed biopsy technique has a lower chance of neoplasm seeding; it is likely that adjuvant chemotherapy has a protective effect against neoplasm seeding; an unfavorable prognosis is expected according to neoplasm seeding results.

show abstract

“…The literature pertinent to this topic reveals that local recurrence was constantly observed in a series of reports on cases in which the biopsy path had not been resected (19,(22)(23)(24)(25)(26)(27) . On the other hand, in studies by Kaffenberger et al (21) and Saghieh et al (28) , in which biopsy paths produced using the percutaneous technique had not been resected, no local recurrence was observed.…”

Section: Discussionmentioning

confidence: 99%

“…In analyzing a set of eight cases of tumor contamination in biopsy paths made in the musculoskeletal system that were reported in the literature (19,(22)(23)(24)(25)(26) , it was observed that percutaneous biopsy was performed in seven of them (19,(22)(23)(24)(25) and open biopsy in one case (26) . Also analyzing the literature, Mohana et al (20) observed two cases of contamination among six cases of open biopsy (33.3%) and three cases of contamination among 20 cases of percutaneous biopsy (15%).…”

Section: Discussionmentioning

confidence: 99%

Contaminação tumoral em trajeto de biópsia de tumores ósseos malignos primários

Oliveira¹,

Lima²,

Mello³

2012

Rev. bras. ortop.

View full text Add to dashboard Cite

Objective: To study factors possibly associated with tumor contamination in the biopsy path of primary malignant bone tumors. Method: Thirty-five patients who underwent surgical treatment with diagnoses of osteosarcoma, Ewing's tumor and chondrosarcoma were studied retrospectively. The sample was analyzed to characterize the biopsy technique used, histological type of the tumor, neoadjuvant chemotherapy used, local recurrences and tumor contamination in the biopsy path. Results: Among the 35 patients studied, four cases of contamination occurred (11.43%): one from osteosarcoma, two from Ewing's tumor and one from chondrosarcoma. There was no association between the type of tumor and presence of tumor contamination in the biopsy path (p = 0.65). There was also no association between the presence of tumor conRev Bras Ortop. 2012;47(5):631-7The authors declare that there was no conflict of interest in conducting this work This article is available online in Portuguese and English at the websites: www.rbo.org.br and www.scielo.br/rbort tamination and the biopsy technique (p = 0.06). On the other hand, there were associations between the presence of tumor contamination and local recurrence (p = 0.01) and between tumor contamination and absence of neoadjuvant chemotherapy (p = 0.02). Conclusion: Tumor contamination in the biopsy path of primary malignant bone tumors was associated with local recurrence. On the other hand, the histological type of the tumor and the type of biopsy did not have an influence on tumor contamination. Neoadjuvant chemotherapy had a protective effect against this complication. Despite these findings, tumor contamination is a complication that should always be taken into consideration, and removal of the biopsy path is recommended in tumor resection surgery.

show abstract

Seeding of osteosarcoma in the biopsy tract of a patient with multifocal osteosarcoma

Abstract: We report a case of multifocal osteosarcoma in a 7-year-old boy who developed iatrogenic seeding of tumor along the biopsy tract. The results of the plain radiograph, CT, and histopathological correlation are presented.

Cited by 27 publications

References 13 publications

Are Biopsy Tracts a Concern for Seeding and Local Recurrence in Sarcomas?

Are Biopsy Tracts a Concern for Seeding and Local Recurrence in Sarcomas?

Neoplasm seeding in biopsy tract of the musculoskeletal system. A systematic review

Contaminação tumoral em trajeto de biópsia de tumores ósseos malignos primários

Contact Info

Product

Resources

About