A B S T R A C TWith the objective of determining the effect of seed rates on the growth parameters, yield components, yield and protein content of bread wheat varieties, a study was conducted at Kulumsa Agricultural Research Center from July to November 2012. Four varieties (Digalu, Danda'a, Kakaba and Shorima) and five seed rates (100, 125, 150, 175 and 200 kg haG 1 ) and RCBD with three replications were used. The results showed that days to 50% heading, days to 90% physiological maturity, plant height, spike length, hectoliter weight and Harvest Index (HI) were affected highly significantly (p<0.01) by the main effects of variety and seed rate whereas, grain protein content was affected highly significantly (p<0.01) only by variety and above ground dry biomass yield was affected highly significantly (p<0.01) only by the main effect of the seed rate. Furthermore, the interaction effect of variety and seed rate significantly affected thousand kernels weight, number of effective tillers and number of kernels per spike and grain yield. The use of 150 kg haG 1 seed rate for variety Shorima resulted in highest thousand kernels weight (39.48 g), number of kernels per spike (60.23) and grain yield (5339.3 kg haG 1 ). From the result of this study, the use of 125 kg haG 1 seed rate for variety Danda'a; 150 kg haG 1 for varieties Shorima and Kakaba and 175 kg haG 1 for variety Digalu were identified for good crop stand and finally the yield.