Fig. 1: Example of a deconstructed science infographic from the biomedical domain [53], with each conceptual metaphorical element classified as a structural, ontological, orientational, or imagistic metaphor. An imagistic metaphor correlates one concept with another employing graphical similarity. Here, the wobbly structure of a cell membrane is graphically described through an irregular patch shape inscribed with stitch marks. An orientational metaphor describes a concept (or system of concepts) based on spatial orientation and composition, e.g., the cell cycle where its stages are arranged in an infinity symbol. An ontological metaphor projects concrete entities onto abstract concepts (e.g., events, actions, states, activities), e.g., presenting ribosomes as cafe workers. A more complex structural metaphor ties one unfamiliar conceptual network or set of processes to another more familiar conceptual network through an entailment relationship, e.g., the properties and functions of the nucleus are represented as a library. Conceptual metaphors may be combined to leverage greater meaning, such as combining the wobbly patch shape with the mitochondrial coffeehouse nested therein to an ontological metaphor for a cellular energy source.