Seeking heterocyclic scaffolds as antivirals against dengue virus

De, Soumik; Aamna, Bari; Sahu, Raghaba; Parida, Sagarika; Behera, Santosh Kumar; Dan, Aritra Kumar

doi:10.1016/j.ejmech.2022.114576

Cited by 42 publications

(16 citation statements)

References 191 publications

(203 reference statements)

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“…Quinoline, an important heterocyclic compound, is a scaffold used in the discovery of many new drug candidates [112] . It has low toxicity to humans on oral absorption and inhalation, with a logP value of 2.04 [113] , [114] . Quinoline derivatives have a wide range of biological properties such as antibacterial, antifungal, anti-cancer, and antiviral activities [115] , [116] , [117] .…”

Section: Inhibitors Of Rdrpmentioning

confidence: 99%

An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges

Chen

et al. 2022

Biochemical Pharmacology

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Section: Inhibitors Of Rdrpmentioning

confidence: 99%

An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges

Chen

et al. 2022

Biochemical Pharmacology

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“…[6][7][8][9][10] The existence of carbocyclic and heterocyclic scaffolds holds a huge significance in biological applications. [11][12][13] As a result, the halocyclization reactions are given much emphasis.…”

Section: Introductionmentioning

confidence: 99%

“…They do so by activating saturated and unsaturated hydrocarbons by forming halonium‐ion intermediates, which are attacked by nucleophiles containing carbon, nitrogen, oxygen, and sulfur [6–10] . The existence of carbocyclic and heterocyclic scaffolds holds a huge significance in biological applications [11–13] . As a result, the halocyclization reactions are given much emphasis.…”

Section: Introductionmentioning

confidence: 99%

Asymmetric Synthesis of Halocyclized Products by Using Various Catalysts: A State‐of‐the‐Art Review

Dan

Sahu

et al. 2022

Eur J Org Chem

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Halogens play a crucial part in synthetic organic chemistry. Halo‐cyclized products hold numerous applications in the pharmaceutical industries, agrochemicals, natural product synthesis, and material chemistry. Thus, this review will discuss the role of various catalysts, such as from metal‐catalysts to organocatalysts, under different conditions to synthesize various halocyclized products. The synthesis and catalytic mechanisms underlying the different asymmetric transformations will also be covered by emphasizing the enantioselectivities, diastereoselectivities, and regioselectivities from the existing pieces of literature.

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“…These have influenced the critical transitions in forming various chemical bonds [42–46] . Natural products with architectural complexity are frequently the motivating factor behind the design of innovative ways for constructing the expected scaffold [47,48] . In principle, designing a pathway for the total synthesis of two or more natural products via a standard intermediate would be more tenacious than designing a synthesis pathway for a single natural product.…”

Section: Introductionmentioning

confidence: 99%

“…[42][43][44][45][46] Natural products with architectural complexity are frequently the motivating factor behind the design of innovative ways for constructing the expected scaffold. [47,48] In principle, designing a pathway for the total synthesis of two or more natural products via a standard intermediate would be more tenacious than designing a synthesis pathway for a single natural product. Specific rules should be evaluated during the design of the synthetic pathways for the total synthesis of natural products.…”

Section: Introductionmentioning

confidence: 99%

Total Synthesis of Natural Products using Gold Catalysis

Dan

Sahu

et al. 2022

Chemistry An Asian Journal

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Gold catalysis is an extremely enthusiastic field of investigation in the catalysis area. The development of alternative, highly inventive, precompetitive techniques based on gold catalysis has paved the way for executing a broad spectrum of chemical transformations from uncomplicated starting materials. The total synthesis of natural products is a complex and more complicated task. An amalgamation of natural product synthesis through goldcatalysis has been a thought-provoking job. The protocol has solved several problems related to the synthesis of numerous complicated natural products. Thus, this review has outlined some of the most notable benchmarks from the last seven years (2015-2021) on gold catalysis and their application in the total synthesis of numerous natural products. The strategy acquired by the authors to accomplish the total synthesis will be elaborately discussed by emphasizing the role of the gold-catalyzed reactions.

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Seeking heterocyclic scaffolds as antivirals against dengue virus

Cited by 42 publications

References 191 publications

An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges

An update on inhibitors targeting RNA-dependent RNA polymerase for COVID-19 treatment: Promises and challenges

Asymmetric Synthesis of Halocyclized Products by Using Various Catalysts: A State‐of‐the‐Art Review

Total Synthesis of Natural Products using Gold Catalysis

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