Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

Khojah, Sohair M; Payne, Philip R. O.; McGuinness, Dagmara; Shiels, Paul G.

doi:10.3390/cells5040038

Cited by 13 publications

(6 citation statements)

References 63 publications

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“…In this study actually demonstrated for Parkinson disease, which however has been shown in rat models to resemble accelerated brain aging(Khojah et al 2016). …”

supporting

confidence: 59%

The dog as a model-animal in comparative sleep spindle research

Borislavov¹

2020

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Dr. Enikő Kubinyi, who supervised this thesis and the efforts that are described hereafter. She trusted my ability when my curriculum vitae could not speak up for me, yet, and provided the necessary means and support for this project to work. Our written exchanges while working on manuscripts together, helped me develop ideas and map my way through the relevant literature. She took the time and patience to review and promote all ideas that came to my mind, while making sure the most urgent goals do not leave our sight. Dr. Gilles van Luijtelaar, who supervised my bachelor and master theses. Who took the time to discuss neuroscience on almost philosophical levels of depth and continued to support me, morally and academically, long after his official role as my teacher had ended. His dry and confrontational, yet cordial humor were always uplifting the spirit of our interactions. Dr. Hein van Schie who supervised my first literature study in psychology and continued to explore ideas with me long after I left the Radboud University of Nijmegen. One of our literature studies became my first publication, which helped me regain confidence in a difficult time. Dr. Torfi Sigurdsson, who after a time that was hard for both of us, did not take it personal that we were a bad match.From the senior university teachers/professors with whom I interacted, but were not my direct/official supervisors I would like to thank:Dr. Arno Koning who first taught me academic writing, the late Dr. Jacques Janssen, Dr. Pieter Medendorp and his then PhD students, now Dr. Frank Léoné and Dr. Ivar Clemens who taught me to use Matlab, our faculty's Statistics professor Dr. Jules Ellis, Dr. Tineke van Rijn for knowing how to ignite interest in brain anatomy and physiology, all of above associated with the Radboud University of Nijmegen. Dr. Jochen Roeper who kept up the intellectual spirit in the otherwise worldly Frankfurt. In the ELTE department of ethology I also had the honor to meet and learn from Dr. Ádám Miklósi, Dr. Attila Andics (whose efforts in organizing the department retreats gave me a chance to socialize more directly with many colleagues), Dr. Péter Pongrácz (whom I thank a visit to a life animal market and my first experiences as a peer-reviewer), Dr. Ákos Pogány and Dr. Tamás Faragó (these two I want to also thank specifically for engaging the department in short-lived, but fun musical projects). I am also grateful for meeting Dr. Claudia Fugazza and Dr. Márta Gácsi and having the opportunity to ask some direct questions about their interesting lines of work. A very special thanks also to Dr. Dorottya Júlia Ujfalussy, for helping out with some highly relevant bureaucratic pressures right in the beginning of my stay (but in that regard also I want to mention and thank Boróka Bereczky, Ágnes Modrovics and Borbála Győri).I would next like to thank a few personal friends from within academia, who at times unofficially acted as "secondary" or "supporting" supervisors, as well as those who worked with me towards shared goals:

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“…In this study actually demonstrated for Parkinson disease, which however has been shown in rat models to resemble accelerated brain aging(Khojah et al 2016). …”

supporting

confidence: 59%

The dog as a model-animal in comparative sleep spindle research

Borislavov¹

2020

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“…There are nine PKC genes in mammals, which are subdivided into three subfamilies: conventional PKC α, β, and γ, neo-PKC δ, ε, θ, η, and atypical PKC ε and ι ( Steinberg, 2008 ). The Parkinsonian phenotype and disruption to dopamine signaling in the basal ganglia are found in AS/AGU (Albino Swiss/Anatomy Glasgow University) rats ( Khojah et al, 2016 ). Knockout of PKC γ in animals, exhibits PD symptoms, such as loss of nigrostriatal dopaminergic neurons and movement disorder ( Shirafuji et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

The function of Golgi apparatus in LRRK2-associated Parkinson’s disease

Wei

Awan²,

Bai³

et al. 2023

Front. Mol. Neurosci.

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Parkinson’s disease (PD) is a chronic neurodegenerative disease associated with the intracellular organelles. Leucine-rich repeat kinase 2 (LRRK2) is a large multi-structural domain protein, and mutation in LRRK2 is associated with PD. LRRK2 regulates intracellular vesicle transport and function of organelles, including Golgi and lysosome. LRRK2 phosphorylates a group of Rab GTPases, including Rab29, Rab8, and Rab10. Rab29 acts in a common pathway with LRRK2. Rab29 has been shown to recruit LRRK2 to the Golgi complex (GC) to stimulate LRRK2 activity and alter the Golgi apparatus (GA). Interaction between LRRK2 and Vacuolar protein sorting protein 52 (VPS52), a subunit of the Golgi-associated retrograde protein (GARP) complex, mediates the function of intracellular soma trans-Golgi network (TGN) transport. VPS52 also interacts with Rab29. Knockdown of VPS52 leads to the loss of LRRK2/Rab29 transported to the TGN. Rab29, LRRK2, and VPS52 work together to regulate functions of the GA, which is associated with PD. We highlight recent advances in the roles of LRRK2, Rabs, VPS52, and other molecules, such as Cyclin-dependent kinase 5 (CDK5) and protein kinase C (PKC) in the GA, and discuss their possible association with the pathological mechanisms of PD.

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“…Chiral molecules are molecules with two mirror-image forms, and the molecule chirality plays an important role in living systems. − The chiral components in living systems usually exist in only one mirror-image form. For example, nucleotides and sugars are in the d -form, while phospholipids and amino acids are in the l -form. , These chiral components are of great significance to various living processes (such as cell metabolism and cell fate). , Chiral drugs can cause different or even opposite effects, such as l -Dopa (a drug used to treat Parkinson’s disease) and ibuprofen (anti-inflammatory and analgesic) …”

Section: Introductionmentioning

confidence: 99%

“…6,7 Chiral drugs can cause different or even opposite effects, such as L-Dopa (a drug used to treat Parkinson's disease) and ibuprofen (anti-inflammatory and analgesic). 8 Currently, chiral research has expanded from organic molecules to inorganic nanoparticles (NPs). 9−12 Due to their specific photochemical properties, chiral nanoparticles have been applied in many fields, such as biological behavior regulation, chiral sensing, enantiomeric separation, chiral catalysis, etc.…”

Section: ■ Introductionmentioning

confidence: 99%

Chiral Cu_2–xSe Nanoparticles for Enhanced Synergistic Cancer Chemodynamic/Photothermal Therapy in the Second Near-Infrared Biowindow

Liu

et al. 2021

ACS Appl. Mater. Interfaces

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Chiral nanomaterials have great potential in improving the clinical therapeutic effect due to the unique chiral selectivity of biosystems. However, such a promising therapeutic strategy has so far received little attention in cancer treatment. Here, we report a first chiral Fenton catalyst, d-/l-penicillamine-modified Cu2–x Se nanoparticles (d-/l-NPs), for enhanced synergistic cancer chemodynamic therapy (CDT) and photothermal therapy (PTT) under the second near-infrared (NIR-II) light irradiation. The chiral effect study of chiral Cu2–x Se NPs on cancer cells shows that d-NPs exhibit stronger CDT-induced cytotoxicity than l -NPs due to the stronger internalization ability. Moreover, the hydroxyl radicals (•OH) produced in d-NP-treated cancer cells via the CDT effect can be further improved by NIR-II light irradiation, thereby increasing the apoptosis of cancer cells. In vivo experiments show that, compared with l-NPs, d-NPs exhibit a stronger photothermal effect on the tumor site under NIR-II light irradiation and could completely eliminate the tumor under the synergistic effect of CDT and PTT. This work shows that the chirality of the surface ligand of the nanomaterials could significantly affect their cancer curative effect, which opens up a new way for the development of anticancer nanomedicine.

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Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

Cited by 13 publications

References 63 publications

The dog as a model-animal in comparative sleep spindle research

The dog as a model-animal in comparative sleep spindle research

The function of Golgi apparatus in LRRK2-associated Parkinson’s disease

Chiral Cu_2–xSe Nanoparticles for Enhanced Synergistic Cancer Chemodynamic/Photothermal Therapy in the Second Near-Infrared Biowindow

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Segmental Aging Underlies the Development of a Parkinson Phenotype in the AS/AGU Rat

Cited by 13 publications

References 63 publications

The dog as a model-animal in comparative sleep spindle research

The dog as a model-animal in comparative sleep spindle research

The function of Golgi apparatus in LRRK2-associated Parkinson’s disease

Chiral Cu2–xSe Nanoparticles for Enhanced Synergistic Cancer Chemodynamic/Photothermal Therapy in the Second Near-Infrared Biowindow

Contact Info

Product

Resources

About

Chiral Cu_2–xSe Nanoparticles for Enhanced Synergistic Cancer Chemodynamic/Photothermal Therapy in the Second Near-Infrared Biowindow