Segmental bone tissue engineering by seeding osteoblast precursor cells into titanium mesh–coral composite scaffolds

Chen, F.; Xue, Feng; Wu, Wei; Ouyang, Hong; Gao, Zhan; Cheng, Xiaobin; Hou, Rui; Mao, Tianqiu

doi:10.1016/j.ijom.2007.06.019

Cited by 21 publications

(8 citation statements)

References 23 publications

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“…Our findings agree with those reported in previous studies where MSCs were used to engineer bone and cartilage tissues (Alhadlaq and Mao, 2003; Guo et al , 2006; Abukawa et al , 2003; Chen et al , 2007; Hou et al , 2007). We observed that human BMSCs maintained their proliferative and multi‐lineage differentiation capacities during in vitro culture and also after seeding in coral scaffolds.…”

Section: Discussionsupporting

confidence: 93%

“…These findings were further confirmed in clinical studies (Zheng et al , 2005). Chen et al (2007) used titanium mesh‐coral scaffolds seeded with osteoblast precursor cells and showed extensive, mechanically viable bone formation that integrated well with the titanium mesh. Titanium may enhance and accelerate bone formation in coral scaffolds.…”

Section: Discussionmentioning

confidence: 99%

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Basic fibroblast growth factor enhances osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells in coral scaffold constructs

Zheng

Jian

et al. 2010

J Tissue Eng Regen Med

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Temporomandibular joint (TMJ) disorders are commonly occurring degenerative joint diseases that require surgical replacement of the mandibular condyle in severe cases. Transplantation of tissue-engineered mandibular condyle constructs may solve some of the current surgical limitations to TMJ repair. We evaluated the feasibility of mandibular condyle constructs engineered from human bone marrow-derived mesenchymal cells (BMSCs). Specifically, human BMSCs were transfected with basic FGF (bFGF) gene-encoding plasmids and induced to differentiate into osteoblasts and chondroblasts. The cells were seeded onto mandibular condyle-shaped porous coral scaffolds and evaluated for osteogenic/chondrogenic differentiation, cell proliferation, collagen deposition and tissue vascularization. Transfected human BMSCs expressed bFGF and were highly proliferative. Osteogenesis was irregular, showing neovascularization around new bone tissue. There was no evidence of bilayered osteochondral tissue present in normal articulating surfaces. Collagen deposition, characteristic of bone and cartilage, was observed. Subcutaneous transplantation of seeded coral/hydrogel hyaluran constructs into nude mice resulted in bone formation and collagen type I and type II deposition. Neovascularization was observed around newly formed bone tissue; bFGF expression was detected in implanted constructs seeded with bFGF expressing hBMSCs. This report demonstrates that engineered porous coral constructs using bFGF gene-transfected human BMSCs may be a feasible option for surgical transplantation in TMJ repair.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 99%

Basic fibroblast growth factor enhances osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells in coral scaffold constructs

Zheng

Jian

et al. 2010

J Tissue Eng Regen Med

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“…[44][45][46][47][48][49][50][51][52] Combinations of coral graft, BMPs and osteoprogenitor cells have shown potent bone healing potential which was comparable to the autologous bone grafting. 44,45,46,48,49 The cellular component of the composite graft originate in the vast majority from bone marrow. However, osteogenically induced adipose tissue stem cells have been utilized with favorable results.…”

Section: Animal Studiesmentioning

confidence: 99%

Is there a role of coral bone substitutes in bone repair?

Pountos

Giannoudis

2016

Injury

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Xenogeneic bone graft materials are an alternative to autologous bone grafting. Among such implants, coralline-derived bone grafts substitutes have a long track record as safe, biocompatible and osteoconductive graft materials. In this review, we present the available literature surrounding their use with special focus on the commercially available graft materials. Corals thanks to their chemical and structural characteristics similar to those of the human cancellous bone have shown great potential but clinical data presented to date is ambiguous with both positive and negative outcomes reported.Correct formulation and design of the graft to ensure adequate osteo-activity and resorption appears intrinsic to a successful outcome.

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“…Chen, et al [42] used titanium mesh coral composite scaffolds for jaw reconstruction. In this experiment, segmental bone grafts were engineered in a predetermined shape via seeding osteoblast precursor cells into titanium mesh-coral composite scaffolds.…”

Section: Single-phase Scaffoldsmentioning

confidence: 99%

Biopolymers for Hard and Soft Engineered Tissues: Application in Odontoiatric and Plastic Surgery Field

et al. 2011

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Abstract:The goal of modern dentistry and plastic surgery is to restore the patient to normal function, health and aesthetics, regardless of the disease or injury to the stomatognathic and cutaneous system respectively. In recent years tissue engineering and regenerative medicine have yielded many novel tissue replacements and implementation strategies. Scientific advances in biomaterials, stem cell isolation, growth and differentiation factors and biomimetic environments have created unique opportunities to fabricate tissues in the laboratory. Repairing of bone and skin is likely to become of clinical interest when three dimensional tissue reconstructive procedures and the appropriate supporting biomimetic materials are correctly assembled. In the present review, we provide an overview of the most promising biopolymers that may find clinical application in dento-maxillo-facial and plastic surgery.

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Segmental bone tissue engineering by seeding osteoblast precursor cells into titanium mesh–coral composite scaffolds

Cited by 21 publications

References 23 publications

Basic fibroblast growth factor enhances osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells in coral scaffold constructs

Basic fibroblast growth factor enhances osteogenic and chondrogenic differentiation of human bone marrow mesenchymal stem cells in coral scaffold constructs

Is there a role of coral bone substitutes in bone repair?

Biopolymers for Hard and Soft Engineered Tissues: Application in Odontoiatric and Plastic Surgery Field

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