Segmental cytomegalovirus colitis mimicking sigmoid tumor in an immunocompetent patient

Abstract

Stem cells for pancreatitis 425 Gastric injury and bacterial overgrowth 433 The effect of visceral fat on SMA configuration 451 Antiplatelet agents in ulcerative colitis 459 Differentiation of BMSCs into intestinal ce 466 GERDOFF ® efficacy in patients with GERD

Cytomegalovirus Diseases of the Gastrointestinal Tract in Immunocompetent Patients: A Narrative Review

“…Regardless of the involved segment, patients may have a fever and a spectrum of severities, including asymptomatic infections, nonspecific symptoms, fulminant disease, and surgical abdomen. In addition to CMV-associated toxic megacolon [ 34 , 35 ], CMV-related intra-abdominal abscess, fistula (rectovaginal, rectovesical), stenosis (small intestine, colon), and hollow organ perforations (stomach, small intestine, and colon) have also been reported in immunocompetent patients [ 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 ]. Compared to immunocompromised patients, more immunocompetent patients present with GI bleeding, shorter symptom onset duration, less extra-GI involvement, and more small intestinal diseases.…”

“…These ulcers may complicate perforation, fistula, abscess, or stricture formation. Polypoid and tumor-like lesions were also noted [ 50 , 94 , 95 , 96 , 97 ]. There were no significant differences between the immunocompetent and immunocompromised groups, except for a study revealing a higher ratio of ulcers in the immunocompromised group (70–35%) [ 13 , 20 , 30 ].…”

The Overlooked Agent: Cytomegalovirus Colitis in an Immunocompetent Patient

“…CMV infection is common among immunocompromised individuals. In this set of patients, the spectrum of disease is very wide, ranging from encephalitis to pericarditis, and usually associated with a considerable morbidity and mortality [ 1 , 2 ].…”

“…In immunocompetent individuals CMV infection is rarer and usually asymptomatic, with a mononucleosis-like syndrome the most common form of symptomatic disease. However, there has been growing evidence that CMV infection in presumed immunocompetent individuals is not as rare as previously thought [ 1 , 2 , 10 ].…”

“…Cytomegalovirus (CMV) colitis is usually associated with immunosuppressed patients, which by the classic definition are individuals who have immunosuppressed associated conditions (human immunodeficiency virus [HIV], oncology diseases, inflammatory bowel disease, transplant patients) or who are submitted to immunosuppressing therapies (for instance, corticosteroids, chemotherapeutic agents or immunomodulation therapies). In immunocompetent individuals CMV infection is rare, usually asymptomatic, and not associated with severe forms of the disease [ 1 , 2 ].…”