2005
DOI: 10.1016/j.mod.2005.04.012
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Segmental Igfbp5 expression is specifically associated with the bent structure of zigzag hairs

Abstract: The murine hair coat consists of four different hair types that are characterised by hair length, the number of medulla columns, and the presence and number of bends. The molecular mechanisms underlying the establishment and maintenance of distinct hair follicle fates are unknown. We identify Igfbp5 as the first molecular marker that distinguishes among different hair follicle types. High-resolution expression analysis revealed that its expression in the medulla of hair shafts is associated with the bend-formi… Show more

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Cited by 40 publications
(57 citation statements)
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References 46 publications
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“…A c c e p t e d M a n u s c r i p t Botchkarev et al, 1999Peters et al, 1999Souza et al, 2006 Alonso and Fuchs, 2006 Aminik et al, 2007Paus and Foitzik, 2004Schlake, 2005aSchlake, 2005bStenn and Paus, 2001 Weger and Schlake,…”
Section: Acknowledgementsmentioning
confidence: 99%
“…A c c e p t e d M a n u s c r i p t Botchkarev et al, 1999Peters et al, 1999Souza et al, 2006 Alonso and Fuchs, 2006 Aminik et al, 2007Paus and Foitzik, 2004Schlake, 2005aSchlake, 2005bStenn and Paus, 2001 Weger and Schlake,…”
Section: Acknowledgementsmentioning
confidence: 99%
“…This result suggests that, in our experimental system, IGFBP5 binds to IGF in order to exert its negative effects on skeletal development. The possibility that the absence of phenotypic effects rests in lack of transgene expression or protein production seems unlikely since the same mutant cDNA clone was shown to be active in a different context (Schlake, 2005).…”
Section: Igfbp5 Has a Negative Effect On Bone Formationmentioning
confidence: 99%
“…Although there has been considerable progress in identifying the factors that regulate whether epidermal stem cell progeny select the hair follicle, sebaceous gland or interfollicular epidermal lineages (Watt et al, 2006), much less is known about how different hair follicle types are specified. Modulation of BMP, Shh, β-catenin or Eda/Edar activity in the epidermis can influence hair follicle phenotype (Botchkarev et al, 2002;Ellis et al, 2003;Huelsken et al, 2001;Mikkola and Thesleff, 2003) and epidermal Igfbp5 expression is required to maintain the kinks in zigzag hair follicles (Schlake, 2005).…”
Section: Introductionmentioning
confidence: 99%