“…In addition to the regional segmentation using neural networks described above, neural network based machine learning algorithms have been used in MR image analysis for approximately 20 years. The primary utilization of neural networks has been in the area of tissue classification (Piraino et al, 1991;Clarke et al, 1993;Cagnoni et al, 1993;Lin et al, 1996a;Lin et al, 1996b;Reddick et al, 1997;Mulhern et al, 1999;Perez et al, 2003;Glass et al, 2003;Valdes-Cristerna et al, 2004;Wagenknecht et al, 2004;Shen et al, 2005;Wismuller et al, 2006, Song et al, 2006. Both supervised backpropogation as well as self organizing maps have been utilized for this purpose.…”