First of all, I would like to thank my supervisor, László G. Nyúl, for directing my eyes to digital image processing when I was his student and for his continuous support ever since.I would also like to thank my colleagues and friends who helped me to realize the results presented here and to enjoy the period of my PhD studies.I am thankful to Dr. Rózsa Dégi, Dr. Attila Kovács, Dr. Géza Thury, Dr. Flóra Hadarits for the OCT image dataset and also thank to Biomedical Application Group for the zebrafish dataset utilized in this research.Last, but not least, I wish to thank my parents and my sister for their constant love and support.