Segregation distortion and differential fitness at the albumin locus in rhesus monkeys (<i>Macaca mulatta</i>)

Smith, David Glenn; Rolfs, Becky

doi:10.1002/ajp.1350070306

Cited by 4 publications

(2 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There is some evidence that transferrin and albumin variants, at least, are not selectively neutral (Smith and Small, 1982;Smith and Rolfs, 1984). In these cases, it is not inconceivable that genetic homogeneity and weak geoclines seen in Macaca mulatta reflect the uniform distribution of selective factors across the range of the species and are thus poor indicators of the intensity of migration and gene flow.…”

Section: I "mentioning

confidence: 92%

Genetics of a wild population of rhesus monkeys (Macaca mulatta): II. The Dunga Gali population in species‐wide perspective

Melnick

Jolly

Kídd

1986

American J Phys Anthropol

View full text Add to dashboard Cite

Genetic variability in a population of wild rhesus monkeys near the village of Dunga Gali, Northwest Frontier Province, Pakistan (Melnick et al., Am. J. Phys. Anthropol. 63:341-360, 1984) was compared to similar variation in other wild-caught rhesus monkeys. Regional samples of rhesus from different parts of Asia all displayed similar amounts of variation (i.e., P and Hi) and were consistently more variable than the Dunga Gali local population. Despite these differences in the level of genetic variation, genetic diversity is fairly evenly distributed across the species range. Thus only 3-9% of the total gene diversity of Macaca mulatta can be attributed to differences among major regions. The differences that do exist tend toward a weak geographic cline with clustering of populations into an eastern and a western group. Both selection and drift/migration models explain this general genetic homogeneity. More genetic (protein and DNA) and zoogeographic data are necessary to choose between these models.

show abstract

Section: I "mentioning

confidence: 92%

Genetics of a wild population of rhesus monkeys (Macaca mulatta): II. The Dunga Gali population in species‐wide perspective

Melnick

Jolly

Kídd

1986

American J Phys Anthropol

View full text Add to dashboard Cite

show abstract

“…One approach to investigating binding sites is to study structural differences in genetic variants that differ in specificity of binding for a particular ligand. In this paper we report the amino acid and cDNA sequence of the serum albumin of the rhesus monkey, Macaca mulatta,l1 and the difference in sequence of two polymorphic forms of macaque albumin that differ in bilirubin binding specificity (6)(7)(8)(9)(10).…”

mentioning

confidence: 99%

cDNA and protein sequence of polymorphic macaque albumins that differ in bilirubin binding.

Watkins¹,

Sakamoto²,

Madison³

et al. 1993

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

The rhesus monkey, Macaca mulatto, exhibits a geographically restricted polymorphism of serum albumins Mac A and Mac B that is recognized by electrophoresis and is associated with a difference in bilirubin-binding parameters. To identify the basis of the polymorphism, the cDNA and protein sequences of serum albumin from M. mulatta were determined. Screening of a Agtll rhesus liver cDNA library yielded a 1988-bp cDNA sequence that encodes the complete amino acid sequence of mature albumin, the entire propeptide, and part of the prepropeptide. Isoelectric focusing and aminoterminal protein sequencing of CNBr fragments of albumin from A/A and B/B homozygotes were performed, and the structural difference was localized to a CNBr fragment (MCB3) spanning residues 124-264. (5), who determined the crystallographic structure of human serum albumin at a resolution of 2.8 A. One approach to investigating binding sites is to study structural differences in genetic variants that differ in specificity of binding for a particular ligand. In this paper we report the amino acid and cDNA sequence of the serum albumin of the rhesus monkey, Macaca mulatta,l1 and the difference in sequence of two polymorphic forms of macaque albumin that differ in bilirubin binding specificity (6-10).It is a paradox that although analbuminemia is extremely rare but apparently tolerable (1, 11), genetic variants of albumin (alloalbumins) are also extremely rare in humans and other species (11-17). More than 40 different human alloalbumins have been identified by protein or DNA sequence analysis, many of them in our laboratory (11-17); however, their cumulative frequency worldwide is only of the order of 1 in 3000. Occasional reports of albumin polymorphism in domestic animals that are based on electrophoretic analysis have appeared, but none of these has apparently been substantiated by structural study. In contrast, by electrophoretic analysis Smith and co-workers (6-9) have identified a pronounced geographic distribution of albumin polymorphism in wild populations of macaque monkeys. Segregation analysis ofthe two phenotypes (Mac A and Mac B) in M. mulatta from India is consistent with the hypothesis of two codominant alleles (Al.ac and Allac) whose frequencies are approximately 0. 3-0.4 and 0.6-0.7, respectively (6, 10

show abstract

The genetic consequences of primate social organization: a review of macaques, baboons and vervet monkeys

Melnick

1987

Genetica

View full text Add to dashboard Cite

Segregation distortion and differential fitness at the albumin locus in rhesus monkeys (Macaca mulatta)

Cited by 4 publications

References 7 publications

Genetics of a wild population of rhesus monkeys (Macaca mulatta): II. The Dunga Gali population in species‐wide perspective

Genetics of a wild population of rhesus monkeys (Macaca mulatta): II. The Dunga Gali population in species‐wide perspective

cDNA and protein sequence of polymorphic macaque albumins that differ in bilirubin binding.

The genetic consequences of primate social organization: a review of macaques, baboons and vervet monkeys

Contact Info

Product

Resources

About