Segregation in the tank of a rotary tablet press machine using experimental and discrete element methods

Ramírez-Aragón, Cristina; Alba‐Elías, Fernando; Marcos, Ana González; Ordieres-Meré, Joaquín

doi:10.1016/j.powtec.2018.01.054

Cited by 17 publications

(5 citation statements)

References 43 publications

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“…Upon entering the reactor, particles move forward propelled by the stirring teeth, as depicted in the comparison of Figure 6 and Figure 2. Additionally, the 15 mm particles display comparable axial movement to the 7.5 mm and 10 mm particles due to friction against the reactor wall [36]. When central axis velocities are low, particles gather at the inlet; yet limited particle numbers result in a relatively low accumulation height.…”

Section: Particles With Different Particle Sizesmentioning

confidence: 96%

Analysis of Waste Tire Particle Movement in a Single Horizontal-Axis Stirred Reactor Based on the Eulerian Discrete Element Method

Hou,

Wu,

Chen

et al. 2024

Sustainability

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The pyrolysis of waste tires has been considered a potential sustainable solution in light of escalating carbon dioxide emissions. Nevertheless, current research indicates a lack of comprehensive understanding regarding the movement of waste tire particles in a single horizontal-axis stirred pyrolysis reactor. This study employed EDEM 2021.2 software to perform comprehensive numerical simulations of a single horizontal-axis stirred pyrolysis reactor, examining the impact of three main production factors—particle size, feed rate, and central axis speed—on particle motion. By acquiring contact data between particles and reactor walls, we illustrated the persistent motion of particles during the operation of the equipment. The research findings suggest that with the rise in rotational speed, there is a corresponding increase in particle accumulation. In high-speed conditions, the interaction between particles and the reactor wall is intensified. The contact level increased by 15.54% (at 3 r/min) and 25.66% (at 5 r/min) with the rise in rotational speed. Furthermore, at an identical rotational speed, the interaction between the larger particle group and the wall surpassed that of the smaller particle group. Doubling the feed rate led to a reduction of over 10% in the contact level between particles and the reaction wall at varying speeds. Through a thorough analysis of various factors influencing particle motion, our objective is to elucidate the motion traits of particles in the reactor, offering crucial theoretical direction and technical assistance to enhance production efficiency and ensure the secure and steady operation of pyrolysis reactors.

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Section: Particles With Different Particle Sizesmentioning

confidence: 96%

Analysis of Waste Tire Particle Movement in a Single Horizontal-Axis Stirred Reactor Based on the Eulerian Discrete Element Method

Hou,

Wu,

Chen

et al. 2024

Sustainability

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“…tends to be heterogeneous. In the pharmaceutical industry, it is one of the most important problems that use granular materials in their processes [13]. The effects of particle size or size distribution on the homogeneity of the content have been studied to confirm accordance with the United States Pharmacopoeia Standard [14,15].…”

Section: Introductionmentioning

confidence: 95%

Effects of particle size and tapped density on the content uniformity of repaglinide - metformin fixed dose tablet combination

Özgen¹

2021

jrp

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The study proposes a solution to content uniformity problem of repaglinide-metformin HCl fixed dose tablet combination with optimization of particle size distribution and tapped density of repaglinide and metformin granules. The developed dosage forms contain less than 0.5% w/w repaglinide and more than 75% w/w metformin hydrochloride in the composition, resulting in content uniformity problems. A route for, minimizing susceptibility to segregation during the tablet press operation, thereby improving content uniformity, was studied through adjusting the particle size distribution and tapped density of the granules. In this study, a new specification in manufacturing method was developed for obtaining repaglinide and metformin granules with particle size distribution and tapped density properties optimized for tablet homogeneity. Specific particle size distribution and tapped density specifications between metformin HCl and repaglinide granules were described as (i) particle size distribution (D90, D50 and D10) of metformin HCl granule should be less than or equal to three times of particle size distribution (D90, D50 and D10) of repaglinide granule; and (ii) tapped density of metformin HCl granule should be less than or equal to two times of tapped density of repaglinide granule. Assay and in vitro dissolution rate analysis were performed by validated HPLC methods.

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“…As a result, the coarse particles slid to the front, whereas fines accumulated near the inclined wall and emptied first into rotating dies, which translated to an excess of fines in the first tablets and a decreasing trend with process time. In general, a comparison of tank geometries and different filling methods demonstrated that segregation can be reduced to the highest extent by continuous feeding of a 'short' tank, which ensures mass flow [65]. Another application of DEM for the simulation of gravity feeding in a rotary press is the study of particle discharge into dies from a rectangular box filled from a feeding pipe via an inclined chute.…”

Section: Studies On Segregation In Rotary Tablet Presses Gravity Feedingmentioning

confidence: 99%

Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

Jakubowska

Ciepluch

2021

Pharmaceutics

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Content uniformity (CU) of the active pharmaceutical ingredient is a critical quality attribute of tablets as a dosage form, ensuring reproducible drug potency. Failure to meet the accepted uniformity in the final product may be caused either by suboptimal mixing and insufficient initial blend homogeneity, or may result from further particle segregation during storage, transfer or the compression process itself. This review presents the most relevant powder segregation mechanisms in tablet manufacturing and summarizes the currently available, up-to-date research on segregation and uniformity loss at the various stages of production process—the blend transfer from the bulk container to the tablet press, filling and discharge from the feeding hopper, as well as die filling. Formulation and processing factors affecting the occurrence of segregation and tablets’ CU are reviewed and recommendations for minimizing the risk of content uniformity failure in tablets are considered herein, including the perspective of continuous manufacturing.

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Segregation in the tank of a rotary tablet press machine using experimental and discrete element methods

Cited by 17 publications

References 43 publications

Analysis of Waste Tire Particle Movement in a Single Horizontal-Axis Stirred Reactor Based on the Eulerian Discrete Element Method

Analysis of Waste Tire Particle Movement in a Single Horizontal-Axis Stirred Reactor Based on the Eulerian Discrete Element Method

Effects of particle size and tapped density on the content uniformity of repaglinide - metformin fixed dose tablet combination

Blend Segregation in Tablets Manufacturing and Its Effect on Drug Content Uniformity—A Review

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