Segregation of Genes for Nitrogen Fixation into Minicells of Escherichiacoll

Aldén, Markus; Rogers, Sue

doi:10.3181/00379727-155-39806

Cited by 3 publications

(2 citation statements)

References 2 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…As all of these problems had been reported in many nanoparticles (e.g., liposomes, micelles, nanospheres, and nanofibers) [1], finding an ideal drug delivery with an optimal size, shape, and surface characteristic including the specific target binding size is still a challenge for scientists. The minicell is described as a type of abnormal division in bacteria, which came from a mutation or stress environment [3], resulting in a small spherical bacterium with a diameter less than 1 μm. Scientists suggested that this was a new term for "nanocells" due to the fact that it has its diameter at the scale of nanometers.…”

Section: Introductionmentioning

confidence: 99%

Tinidazole Delivery Improved by Nanosized Minicells Originated fromLeuconostoc mesenteroides

Kinh

Anh

Jovel

et al. 2019

Journal of Nanomaterials

View full text Add to dashboard Cite

A nanoparticle originating from natural products used as a drug delivery is considered as one of the indispensable issues in the pharmaceutical field. Increasing the bioavailability of a drug and prolonging the effect of the drug are important. Tinidazole is an antifungal agent that has absorption interfered by food. This study reported the ability of Leuconostoc mesenteroides VTCC B-871 in producing nanosized minicells used as drug delivery for tinidazole to improve the passage to the eaten mouse intestinal membrane. By using a scanning electron microscope and a transmission electron microscope, the morphology of the minicell loading drug was observed. The spherical shape and size (400 nm) of minicells did not change over time when kept in buffered saline gelatin and packaged with tinidazole. Based on Box-Behnken design, the optimal conditions were selected for actual encapsulation. Minicells could encapsulate tinidazole approximately to 90% which was determined by high-performance liquid chromatography analysis. The maximal concentration of tinidazole released from minicells was 70% at pH 3.4 and 55% at pH 7.2, respectively. The absorption ability of tinidazole packaging minicells was quantified in mice. Tinidazole loading minicells could be absorbed faster than tinidazole alone in fed mice via oral administration. The study assessed that the absorption of water-insoluble tinidazole could be improved by Leuconostoc minicells without inhibition by food effects.

show abstract

Section: Introductionmentioning

confidence: 99%

Tinidazole Delivery Improved by Nanosized Minicells Originated fromLeuconostoc mesenteroides

Kinh

Anh

Jovel

et al. 2019

Journal of Nanomaterials

View full text Add to dashboard Cite

show abstract

“…Minicell is described as a type of abnormal division in bacteria, which came from mutation or stress environment[3] , resulting in a small spherical bacterium whose diameter is less than 1 µm. Scientists suggested that this was a new term for nanocells, due to the fact that it has its diameter in the range of a nanometer.…”

mentioning

confidence: 99%

Studies on Tinidazole Delivery from Nano-sized Minicells Originated from Leuconostoc mesenteroides

Vu¹,

Nguyễn²,

Nguyen³

2019

pharmaceutical-sciences

View full text Add to dashboard Cite

Vu et al.: Improvement of Absorption of Tinidazole by Nano-sized MinicellsThis study reported the ability of Leuconostoc mesenteroides VTCC B-871 to produce nano-sized minicells for the delivery of tinidazole to improve permeation through mice intestinal membrane. Using scanning electron microscope and transmission electron microscope, morphology of minicells while loading the drug was observed. Minicells did not change spherical shape and size (400 nm) over the time kept in buffered saline gelatin containing tinidazole. Based on Box-Behnken design, the optimal conditions were selected for actual encapsulation. Minicells could encapsulate tinidazole approximately to 90 % as determined by high performance liquid chromatographic analysis. Maximum concentration of tinidazole released from minicells was 70 % at pH 3.4 and 55 % at pH 7.2, respectively. Absorption of tinidazole from minicells was quantified in mice. Tinidazole could be absorbed faster from the minicells than tinidazole alone in fed mice upon oral administration. The study demonstrated that the absorption of water-insoluble tinidazole with food could be improved by Leuconostoc minicells.

show abstract

Cloning of the entire region for nitrogen fixation from Klebsiella pneumoniae on a multicopy plasmid vehicle in Escherichia coli

1979

View full text Add to dashboard Cite

Segregation of Genes for Nitrogen Fixation into Minicells of Escherichiacoll

Cited by 3 publications

References 2 publications

Tinidazole Delivery Improved by Nanosized Minicells Originated fromLeuconostoc mesenteroides

Tinidazole Delivery Improved by Nanosized Minicells Originated fromLeuconostoc mesenteroides

Studies on Tinidazole Delivery from Nano-sized Minicells Originated from Leuconostoc mesenteroides

Cloning of the entire region for nitrogen fixation from Klebsiella pneumoniae on a multicopy plasmid vehicle in Escherichia coli

Contact Info

Product

Resources

About