Segregation of immunoglobulin heavy chain constant region genes in multiple sclerosis sibling pairs

Yu, John S.; Pandey, Janardan P.; Massacesi, Luca; Lincoln, Robin; Usuku, Koichiro; Seboun, Eric

doi:10.1016/0165-5728(93)90218-n

Cited by 13 publications

(1 citation statement)

References 28 publications

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“…Linkage studies. Immunoglobulin allotypes for the heavy chain loci IgG1, IgG2 and IgG3 were determined through a standard hemagglutination inhibition technique and IghC alleles were detected by RFLP with the H24/Sac I probe/enzyme combination (84). Combining both methods, haplotype sharing could be determined in 20 affected sibpairs derived from a panel of set of 40 sibling pairs.…”

Section: Immunoglobulin Heavy Chain Genesmentioning

confidence: 99%

Genetics of Demyelinating Diseases

Oksenberg

Seboun

1996

Brain Pathology

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Multiple sclerosis (MS), the prototypic demyelinating disease in humans, is the most common cause of acquired neurological dysfunction arising between early to mid adulthood. MS is an inflammatory disorder and is believed to result from an autoimmune response, directed against myelin proteins and perhaps other antigens, resulting in demyelination and dense astrogliosis. A genetic component in MS is indicated by an increased relative risk to siblings compared to the general population (lambda s) of 20-40, and an increased concordance rate in monozygotic compared to dizygotic twins. Association and/or linkage studies to candidate genes have yielded a considerable number of reports showing significant genetic effects for the major histocompatibility complex (MHC), immunoglobulin heavy chain, T cell antigen receptor, and myelin basic protein loci. With the exception of the MHC, however, these results have been difficult to replicate or apply beyond isolated populations. Recently, a multi-analytical genomic screen effort was completed to identify genomic regions potentially harboring MS susceptibility genes. Nineteen such regions were identified. The data confirm the reported genetic effect of the MHC region. However, no single locus generated overwhelming evidence of linkage. These results suggest a multifactorial etiology, including both environmental and multiple genetic factors of moderate effect.

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Section: Immunoglobulin Heavy Chain Genesmentioning

confidence: 99%