Segregation of Visual Response Properties in the Mouse Superior Colliculus and Their Modulation during Locomotion

Ito, Setsuro; Feldheim, David A.; Litke, A. M.

doi:10.1523/jneurosci.3689-16.2017

Cited by 81 publications

(119 citation statements)

References 63 publications

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“…Where there is overlap, our measurements in awake animals are also consistent with a recent study by Ito et al . () reporting similar distributions of spatial frequency preference, linearity of spatial summation, and prevalence of orientation and direction selectivity.…”

Section: Discussionmentioning

confidence: 83%

“…; Ito et al . ; Shi et al . ), consistent with the projection of direction selective retinal ganglion cells (Kim et al .…”

Section: Discussionmentioning

confidence: 99%

“…One potentially puzzling observation in both our work and that of Ito et al . () is the prevalence of largely linear responses to counterphase modulated gratings, despite a general prevalence of ON–OFF responses for flashed stimuli and less linear responses to drifting gratings. A spiking threshold might hide the second‐harmonic response to counterphase modulation if the input of one (ON or OFF) subfield is substantially stronger than the other and, indeed, most sSC neurons preferred black stimuli.…”

Section: Discussionmentioning

confidence: 99%

“…) and can depend on behavioural state including locomotion (Ito et al . ). These effects of behaviour and anaesthesia are similar to those observed in the LGN and V1 of mouse (Vaiceliunaite et al .…”

Section: Introductionmentioning

confidence: 97%

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Visual response properties of neurons in the superficial layers of the superior colliculus of awake mouse

Franceschi

Solomon

2018

The Journal of Physiology

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Key points In rodents, including mice, the superior colliculus is the major target of the retina, but its visual response is not well characterized.In the present study, extracellular recordings from single nerve cells in the superficial layers of the superior colliculus were made in awake, head‐restrained mice, and their responses to visual stimuli were measured.It was found that these neurons show brisk, highly sensitive and short latency visual responses, a preference for black over white stimuli, and diverse responses to moving patterns.At least five broad classes can be defined by variation in functional properties among units.The results of the present study demonstrate that eye movements have a measurable impact on visual responses in awake animals and show how they may be mitigated in analyses. AbstractThe mouse is an increasingly important animal model of visual function in health and disease. In mice, most retinal signals are routed through the superficial layers of the midbrain superior colliculus, and it is well established that much of the visual behaviour of mice relies on activity in the superior colliculus. The functional organization of visual signals in the mouse superior colliculus is, however, not well established in awake animals. We therefore made extracellular recordings from the superficial layers of the superior colliculus in awake mice, while the animals were viewing visual stimuli including flashed spots and drifting gratings. We find that neurons in the superficial layers of the superior colliculus of awake mouse generally show short latency, brisk responses. Receptive fields are usually ‘ON–OFF’ with a preference for black stimuli, and are weakly non‐linear in response to gratings and other forms of luminance modulation. Population responses to drifting gratings are highly contrast sensitive, with a robust response to spatial frequencies above 0.3 cycles degree−1 and temporal frequencies above 15 Hz. The receptive fields are also often speed‐tuned or direction‐selective. Analysis of the response across multiple stimulus dimensions reveals at least five functionally distinct groups of units. We also find that eye movements affect measurements of receptive field properties in awake animals, and show how these may be mitigated in analyses. Qualitatively similar responses were obtained in urethane‐anaesthetized animals, although receptive fields in awake animals had higher contrast sensitivity, shorter visual latency and a stronger response to high temporal frequencies.

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Section: Discussionmentioning

confidence: 83%

“…; Ito et al . ; Shi et al . ), consistent with the projection of direction selective retinal ganglion cells (Kim et al .…”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 97%

See 2 more Smart Citations

Visual response properties of neurons in the superficial layers of the superior colliculus of awake mouse

Franceschi

Solomon

2018

The Journal of Physiology

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“…; Gale & Murphy, ; Ito et al . ), they found that in both conditions most neurons in the SC respond to both white and black spots on a grey background, and that their On and Off subfields were overlapping. Interestingly, they found differences in the response of SC neurons to drifting gratings.…”

mentioning

confidence: 92%

Neurons in the superior colliculus wake up to see things differently

Triplett

2018

The Journal of Physiology

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Cell type‐ and layer‐specific convergence in core and shell neurons of the dorsal lateral geniculate nucleus

Okigawa

Yamawaki

Ito

et al. 2020

J of Comparative Neurology

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Over 40 distinct types of retinal ganglion cells (RGCs) generate parallel processing pathways in the visual system. In mice, two subdivisions of the dorsal lateral geniculate nucleus (dLGN), the core and the shell, organize distinct parallel channels to transmit visual information from the retina to the primary visual cortex (V1). To investigate how the dLGN core and shell differentially integrate visual information and other modalities, we mapped synaptic input sources to each dLGN subdivision at the cell-type level with G-deleted rabies viral vectors. The monosynaptic circuit tracing revealed that dLGN core neurons received inputs from alpha-RGCs, Layer 6 neurons of the V1, the superficial and intermediate layers of the superior colliculus (SC), the internal ventral LGN, the lower layer of the external ventral LGN (vLGNe), the intergeniculate leaf, the thalamic reticular nucleus (TRN), and the pretectal nucleus (PT). Conversely, shell neurons received inputs from alpha-RGCs and direction-selective ganglion cells of the retina, Layer 6 neurons of the V1, the superficial layer of the SC, the superficial and lower layers of the vLGNe, the TRN, the PT, and the parabigeminal nucleus. The present study provides anatomical evidence of the cell typeand layer-specific convergence in dLGN core and shell neurons. These findings suggest that dLGN core neurons integrate and process more multimodal information along with visual information than shell neurons and that LGN core and shell neurons integrate different types of information, send their own convergent information to discrete populations of the V1, and differentially contribute to visual perception and behavior.

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Segregation of Visual Response Properties in the Mouse Superior Colliculus and Their Modulation during Locomotion

Cited by 81 publications

References 63 publications

Visual response properties of neurons in the superficial layers of the superior colliculus of awake mouse

Visual response properties of neurons in the superficial layers of the superior colliculus of awake mouse

Neurons in the superior colliculus wake up to see things differently

Cell type‐ and layer‐specific convergence in core and shell neurons of the dorsal lateral geniculate nucleus

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