Seguridad y eficacia de la cifoplastia en el tratamiento de la enfermedad tumoral de la columna vertebral

García-Maroto, Roberto; García-Coiradas, J.; Milano, G.; Cebrián, Juan Luis; Marco, Fernando; López-Durán, L.

doi:10.1016/j.recot.2015.05.003

Cited by 3 publications

(3 citation statements)

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“…BKP has been reported to restore height to a fractured vertebra and improve the kyphotic deformity of the vertebral body by over 50 % if the BKP is performed within 3 months of the onset of pain in the osteoporotic population [ 13 ]. BKP and percutaneous vertebroplasty have also been used successfully in the setting of MM to prevent deformity and treat pain [ 15 – 17 , 28 , 29 ]. We found that vertebral body height was only restored by a small amount in our cohort, but importantly, no further height was lost after BKP was performed.…”

Section: Discussionmentioning

confidence: 99%

“…Our follow-up is reported at 6 weeks post-treatment as we do not have sufficient data from 3 and 6 month follow-up time points. Patients often did not attend subsequent appointments for varying reasons, and some developed additional lesions which could confound the outcomes [ 15 , 29 ]. It is our experience that patients cannot reliably distinguish between symptoms from treated and new fractures.…”

Section: Discussionmentioning

confidence: 99%

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Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

Malhotra

Butler

et al. 2016

BMC Cancer

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BackgroundMultiple myeloma osteolytic disease affecting the spine results in vertebral compression fractures. These are painful, result in kyphosis, and impact respiratory function and quality of life. We explore the impact of time to presentation on the efficacy of spinal treatment modalities.MethodsWe retrospectively reviewed 183 patients with spinal myeloma presenting to our service over a 2 year period.ResultsMedian time from multiple myeloma diagnosis to presentation at our centre was 195 days. Eighty-four patients (45.9 %) were treated with balloon kyphoplasty and the remainder with a thoracolumbar-sacral orthosis as per our published protocol. Patients presenting earlier than 195 days from diagnosis had significant improvements in patient reported outcome measures: EuroQol 5-Dimensions (p < 0.001), Oswestry Disability Index (p < 0.001), and Visual Analogue Pain Score (p < 0.001) at follow-up, regardless of treatment. Patients presenting after 195 days, however, only experienced benefit following balloon kyphoplasty, with no significant benefit from non-operative management.ConclusionVertebral augmentation and thoracolumbar bracing improve patient reported outcome scores in patients with spinal myeloma. However, delay in treatment negatively impacts clinical outcome, particularly if managed non-operatively. It is important to screen and treat patients with MM and back pain early to prevent deformity and improve quality of life.Electronic supplementary materialThe online version of this article (doi:10.1186/s12885-016-2495-7) contains supplementary material, which is available to authorized users.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

Malhotra

Butler

et al. 2016

BMC Cancer

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“…In the case of small trauma, easy operation and high safety led to an increased usage of the minimally invasive surgery in the treatment of osteolytic tumor of the spine with an excellent curative effect [4, 20]. Ha [21] followed up 27 patients with MM, who had undergone bone cement treatment and demonstrated rapid pain relief post-surgery.…”

Section: Discussionmentioning

confidence: 99%

PKP/PVP combine chemotherapy in the treatment of multiple myeloma patients with vertebral pathological fractures: minimum 3-year follow-up of 108 cases

Yao

2019

J Orthop Surg Res

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BackgroundMultiple myeloma (MM) is a blood system malignant tumor, which often leads to osteolytic bone destruction, and the vertebral column is the primary site of involvement. However, the efficacy and prognosis of percutaneous kyphoplasty/vertebroplasty (PKP/PVP) for simple vertebral pathological fractures in patients with multiple myeloma are not yet unified. The primary objective of this study was to investigate the efficacy and prognosis of PKP/PVP in the treatment of multiple myeloma patients with vertebral pathological fractures.MethodsA total of 108 patients with MM from Beijing Chao-Yang Hospital from 2007 to 2013 were enrolled. Of these, 52 patients underwent PKP/PVP surgery and chemotherapy (surgery group) and 56 received only chemotherapy (chemotherapy group). The age, gender, International Staging System (ISS), fracture location, segment, visual analog scale (VAS), Oswestry Disability Index (ODI), comprehensive treatment satisfaction, stem cell transplantation, overall survival (OS), mortality rate, and the cause of death of patients were recorded; the mean follow-up time was 42.46 months.ResultsThe average age of patients in surgery and chemotherapy groups was 60.8 years and 58.1 years, and the mean survival time was 41.98 months and 43.30 months, respectively. The VAS score at 1 month and last follow-up after treatment in surgery group were significantly lower than those in the chemotherapy group (P < 0.05); the ODI at 1 month after treatment in the surgery group was significantly lower than that in the chemotherapy group (P < 0.05); no significant difference was observed in the 3-year mortality rate between surgery and chemotherapy groups. The number of patients who developed activity disorder in the surgery group was significantly less than that in the chemotherapy group (P < 0.05). The OS of patients in ISS stage III was significantly less than that in ISS stages I and II (P < 0.05).ConclusionsPKP/PVP surgery can greatly relieve the pain caused by fractures, reduce the risk of being completely bedridden and pulmonary infection, and improve the quality of life of patients; however, it did not affect mortality rate and overall survival time in patients.Trial registrationAs this was a retrospective study, it did not require ethical approval; all patients had signed informed consent when they received treatment, and all treatment options were voluntary.

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Strategies for interventional therapies in cancer-related pain—a crossroad in cancer pain management

Allano

George

Minello

et al. 2019

Support Care Cancer

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Seguridad y eficacia de la cifoplastia en el tratamiento de la enfermedad tumoral de la columna vertebral

Cited by 3 publications

References 30 publications

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

Spinal disease in myeloma: cohort analysis at a specialist spinal surgery centre indicates benefit of early surgical augmentation or bracing

PKP/PVP combine chemotherapy in the treatment of multiple myeloma patients with vertebral pathological fractures: minimum 3-year follow-up of 108 cases

Strategies for interventional therapies in cancer-related pain—a crossroad in cancer pain management

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