Seinäjoki Adult Asthma Study (SAAS): a protocol for a 12-year real-life follow-up study of new-onset asthma diagnosed at adult age and treated in primary and specialised care

Kankaanranta, Hannu; Ilmarinen, Pinja; Kankaanranta, Terhi; Tuomisto, Leena E.

doi:10.1038/npjpcrm.2015.42

Cited by 28 publications

(65 citation statements)

References 32 publications

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“…Smokers and patients with co-morbidities were not excluded making this a real life study. During 1999–2002 a considerable proportion of novel asthma diagnoses in the region were made at Seinäjoki Central Hospital and >94% of the patients obtaining diagnosis of asthma in this hospital at the study period took part in the study [18]. Therefore, this study population well represents a primary care population with asthma.…”

Section: Discussionmentioning

confidence: 99%

“…Therefore, this study population well represents a primary care population with asthma. However, patients with very mild or seasonal asthma may have been excluded since patients had to fill the strict lung function criteria [18]. …”

Section: Discussionmentioning

confidence: 99%

“…The study protocol and the inclusion and exclusion criteria have been previously published [18]. Study population consists of 260 consecutive patients who were diagnosed with adult-onset asthma in 1999–2002 by a respiratory physician (Figure 1).…”

Section: Methodsmentioning

confidence: 99%

“…Patients were recruited from the diagnostic visit. Diagnosis was based on typical symptoms, and it was confirmed by objective lung function measurements [18]. Smokers (current or ex-) and patients with co-morbidities were included in the study.…”

Section: Methodsmentioning

confidence: 99%

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Daily physical activity and lung function decline in adult-onset asthma: a 12-year follow-up study

Loponen

Ilmarinen

Tuomisto

et al. 2018

European Clinical Respiratory Journal

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Background: There is a lack of knowledge on the association between daily physical activity and lung function in patients with asthma. Objective: This study aims to examine the association between daily physical activity and asthma control, lung function, and lung function decline in patients with adult-onset asthma. Design: This study is part of Seinäjoki Adult Asthma Study (SAAS), where 201 patients were followed for 12 years after asthma diagnosis. Daily physical activity was assessed at follow-up by a structured questionnaire and used to classify the population into subgroups of low (≤240 min) or high (>240 min) physical activity. Three spirometry evaluation points were used: 1. diagnosis, 2. the maximum lung function during the first 2.5 years after diagnosis (Max0-2.5), 3. follow-up at 12 years. Results: High physical activity group had slower annual FEV1 (p<0.001) and FVC (p<0.018) decline. Additionally, the high physical activity group had higher FEV1 values at follow-up, and higher FEV1/FVC ratios at follow-up and diagnosis. There was no difference in BMI, smoking, medication, or frequency of physical exercise between high and low physical activity groups. Differences remained significant after adjustments for possible confounding factors. Conclusion: This is the first demonstration of an association between long-term FEV1 decline and daily physical activity in clinical asthma. Low physical activity is independently associated with faster decline in lung function. Daily physical activity should be recommended in treatment guidelines in asthma.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Daily physical activity and lung function decline in adult-onset asthma: a 12-year follow-up study

Loponen

Ilmarinen

Tuomisto

et al. 2018

European Clinical Respiratory Journal

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“…1. The study protocol has been published separately [22]. Patients were consecutively included in the study if all of the following criteria were fulfilled: 1) new-onset asthma diagnosed by respiratory specialist 2) confirmation of diagnosis by lung function measurements showing reversible obstruction 3) symptoms of asthma 4) age ≥15 years.…”

Section: Patients and Study Designmentioning

confidence: 99%