The purpose of this study is to introduce a new and efficient virtual model-based ergonomic simulation framework utilizing recent anthropometric data for a digitalized main control room in an advanced nuclear power plant. The system interface of the main control room has been undergoing digitalization via various information and control consoles. Console operators often face human–computer interactive problems due to inappropriate console design. Computational models with a process of visual perception and variables of anthropometric data are developed for designing and evaluating operator consoles with the requirements of human factor guidelines. From the 3D computational model and simulation application, console dimensions and a designing test module, which would be used for designing suitable consoles with safety concerns in a nuclear plant, are proposed. To efficiently carry out console design and evaluation feedback, an intelligent design review system comprising a virtual modeling and simulation framework is developed. The proposed automated and virtual design review system provides console design efficiency and evaluation effectiveness. This study may influence methods of employing suitable design concepts with various anthropometric data in many areas with safety concerns and may show a feasible solution to designing and evaluating the main control room.