The auxiliary feedwater electric pump, which is vital in nuclear power units, demands exceptional seismic reliability. The impact of the seismic excitation direction on the seismic response of the complex auxiliary feedwater electric pump structure remains inadequately understood, thereby introducing uncertainties into seismic analysis and equipment installation procedures. To address this challenge, this study centers on a representative horizontal multi-stage centrifugal pump based on the finite element model and modal analysis. Utilizing the response spectrum method and the square root of the sum of the squares (SRSS) vibration pattern superposition principle, the research comprehensively explores the seismic response characteristics of individual pressure-bearing components and key rotor positions under seismic excitation from various angles. Findings reveal intricate variations in maximum stress and displacement responses for each pressure-bearing component under safe shutdown earthquake (SSE) level seismic excitation, corresponding to different input angles of seismic spectra. In assessing the seismic operability of the clearance between the impeller and the stator, the direction near 45° exhibits the maximum displacement response, highlighting the need for focused attention in testing and verification checks. The methodologies and conclusions presented in this paper offer valuable insights for designing, optimizing, and installing horizontal multi-stage centrifugal pumps, including auxiliary feedwater electric pumps, providing valuable guidance for future applications in the field.