On May 11, 2011 an earthquake of magnitude 5.1 ( TeX ) struck Murcia region causing nine casualties and damage to buildings and infrastructures. Even if the main characteristics of the event would classify it as a moderate earthquake, the maximum Peak Ground Acceleration (PGA) registered (equal to 0.37 g) exceeded significantly local code provisions in terms of hazard at the site. This high PGA was a result of directivity effects in the near source region. An overview of earthquake characteristics and damage observed is provided. Notwithstanding the lack of proper structural design characterizing building stock in the area, most of the losses were caused by non-structural damage. According to in field observations, it emerges that masonry infills provided additional, “not designed”, strength to reinforced concrete (RC) buildings. Observed damage data, collected after the earthquake, are shown and compared to the results of a simplified approach for nonstructural damage assessment of RC infilled structures (FAST vulnerability approach). The latter comparison provided a fair accordance between observed data and analytical results