This paper presents an experimental and numerical study on a new hybrid structural system with RC frame and stiffened masonry wall. Summarily, four different connection types between frames and reinforced masonry walls were divided in this investigation. Firstly, construction for different connecting modes were described in detail and then tests of four specimens under reciprocating load were carried out to study the influence of connection modes on failure modes and hysteretic response. Results reveal that all these specimens have higher ductility and lower stiffness degradation than RC frame structure and frame-shear wall structure. Furthermore, the specimen of type Ⅳ shows lower ductility and higher ultimate bearing capacity and energy dissipation than the other three because of the more effective connection mode to avoid weak load-bearing point and unsatisfied failure mode. Finally, FE models were established to simulate the seismic behavior of testing specimens. Numerical results can accurately predict the failure modes and cyclic response except for failing to fully replicate the pinching response due to ignorance of bond slip effect. Study results will provide solid support and reference for the further nonlinear seismic response analysis and for the application in practical engineering for this new proposed hybrid structural system.