During strong earthquakes, structural damage usually occurs, resulting in a degradation of the overall stiffness of the affected structures. This degradation produces a modification in the dynamic properties of the structures, for instance, in the fundamental period of vibration (T1). Hence, the variation of T1 could be used as an indicator of seismic structural damage. In this article, a seismic damage assessment in four generic typologies of steel buildings was carried focused on verifying the variation of T1. To do so, several seismic damage states were calculated using the maximum inter-story drift ratio, MIDR, and following the Risk-UE guidelines. Then, a series of probabilistic nonlinear static analyses was implemented using Monte Carlo simulations. The probabilistic approach allows one to vary the main mechanical properties of the buildings, thus analyzing in this research 4000 buildings (1000 building samples for each of the four generic typologies). The variation of T1 was estimated using the capacity spectrum, and it was related to the MIDR for each damage state. As a main result of this study, the expected variation of T1 for several damage states is provided. Finally, a proposal for a seismic damage preventive “semaphore” and fragility curves are presented. These results may be useful as parameters or criteria in the evaluation of on-site structural monitoring for steel buildings.