In the last 20 years, there have been a series of seismic events in Italy that have caused serious damage to civil and building structures. This has led to a significant increase in the use of concrete for the reconstruction of new structures and the repair of existing structures damaged by earthquakes. At the same time, the concrete industry is responsible for the most significant environmental damage during the life cycle of the built environment. The environmental disadvantages characterizing the concrete industry are related to the constant growth of the exploitation of natural aggregates. Therefore, it is necessary to use alternative and innovative aggregates that provide good concrete performance and lower environmental impacts. In this study, a very promising route from an environmental point of view is given by the use of artificial aggregates from industrial waste as substitutes for natural aggregates. An innovative low cost and energy saving granulation process has been employed to produce lightweight aggregates using fly ash from the incineration of municipal solid waste and ground granulated blast furnace slag. The final aim of this research is to demonstrate the environmental sustainability of artificial aggregates, through a comparison of three different mixtures.