The spatial distribution of the social and seismic structural vulnerabilities in Zihuatanejo (ZIH), Guerrero, Mexico was estimated. Social vulnerability was assessed considering twelve indicators, including parameters such as access to health services, education, housing, employment, and unfavorable family conditions. Seismic structural vulnerability was estimated by characterizing the structural characteristics of local houses, assessing the type and age of construction, and the quality of building materials. Surveyed households were randomly selected from a statistically significant sample. Our findings indicate that in the western and eastern areas of ZIH the population has high and very high social vulnerability. The main factors that condition these high levels of social vulnerability are low-income female-headed families, and households with marginal access to information technology such as internet and telephone. Although seismic ground amplification in ZIH is relatively low, the areas to the west and southwest of the city are zones where the impact of strong earthquakes to constructions may be greater than in other areas. In particular, the districts of Lázaro Cárdenas, Benito Juárez, Cuauhtémoc, Emiliano Zapata, Las Mesas, Buenos Aires, Lomas del Quebrachal, and Lomas del Riscal would be affected. In general, houses susceptible to be damaged by the impact of an earthquake are in regions where the population is socially more vulnerable. More than 50% of the population and 30% of the houses have high and very high level of social and structural vulnerability. Our results provide information to the local and federal authorities to strengthen their civil protection and hazard mitigation plans.