High-quality, normal-incidence seismic reflection data confirm that tectonic deformation in the central Indian Ocean occurs at two spatial scales: whole lithosphere folding with wavelengths varying between 100 and 300 km, and compressional reactivation of crustal faults with a characteristic spacing of c. 5 km. Faults penetrate through the crust and probably into the upper mantle. Both types of deformation are driven by regional large intraplate stresses originating from the Indo-Eurasian collision. Numerical modelling of the spatial and temporal relationships between these two modes of deformations shows that, in agreement with geophysical observations, crustal faults are reactivated first with stick-slip behaviour. Subsequent lithospheric folding does not start until horizontal loading has significantly reduced the mechanical strength of the lithosphere, as predicted by elasto-plastic buckling theory. Modelling suggests that lithospheric folding does not develop in the absence of fault reactivation. Crustal fault reactivation, therefore, appears to be a key facilitating mechanism for oceanic lithospheric buckling in the central Indian Ocean.