San Salvador Metropolitan Area (MASS) is an urbanized territory in the country of El Salvador, located between the San Salvador volcano and the Ilopango caldera, in a sub-flat area called “Valle de las Hamacas” (Valley of the Hammocks). The high seismicity of this area is due to the subduction zone of the Cocos plate that causes strong seismic events such as the earthquakes that occurred on 13 January (7.6 Mw) and 13 February 2001 (6.6 Mw). As part of the international cooperation project between Italy (AICS) and El Salvador University, the CASTES project focussed on natural hazards in the territory of El Salvador was launched. Therefore, 2D simulations are carried out along two sections to evaluate the Local Seismic Response (LSR) in the Southeast part of MASS territory. Results show spatially variable amplifications (from 3 to 6.5) in the period ranging 0.1–0.7 s and evidence of lateral FA variations that can be calculated only through 2D numerical analyses. Two amplified periods are recognised, 0.1–0.5 s and 0.4–0.8 s, due to the presence of two types of subsoil volcanic deposits: the shallow and soft Tierra Blanca deposits and the deeper and stiffer Volcanic ash and Tuff.