The seismic performance of monopiled offshore wind turbine (OWT) structures was evaluated numerically. The aim was to analyze offshore wind farm sites on complicated layered seabed with high seismicity. Following pile soil analysis (PISA) model, three-dimensional (3D) numerical evaluations were undertaken for two separate locations under two independent seismic events. The effects of pile diameter, depth, site impact owing to transverse soil layering, uni-directional and multi-directional seismic loading and seismic acceleration magnitude are presented. Dynamic impedance depth variation and site response analysis via lateral displacement, lateral soil response and Fourier response amplitude are explored in frequency and time domain. In a seismic zone with stratified soil, pile diameter has a greater influence. Variations in soil profile affect wind turbine performance and seismic sensitivity. This research will give a strong platform for later studies to recommend a safe wind farm site based on simulation results.