This paper numerically investigates the required superplasticizer (SP) demand for self-consolidating concrete (SCC) as a valuable information source to obtain a durable SCC. In this regard, an adaptive neuro-fuzzy inference system (ANFIS) is integrated with three metaheuristic algorithms to evaluate a dataset from non-destructive tests. Hence, five different non-destructive testing methods, including J-ring test, V-funnel test, U-box test, 3 min slump value and 50 min slump (T50) value were performed. Then, three metaheuristic algorithms, namely particle swarm optimization (PSO), ant colony optimization (ACO) and differential evolution optimization (DEO), were considered to predict the SP demand of SCC mixtures. To compare the optimization algorithms, ANFIS parameters were kept constant (clusters = 10, train samples = 70% and test samples = 30%). The metaheuristic parameters were adjusted, and each algorithm was tuned to attain the best performance. In general, it was found that the ANFIS method is a good base to be combined with other optimization algorithms. The results indicated that hybrid algorithms (ANFIS-PSO, ANFIS-DEO and ANFIS-ACO) can be used as reliable prediction methods and considered as an alternative for experimental techniques. In order to perform a reliable analogy of the developed algorithms, three evaluation criteria were employed, including root mean square error (RMSE), Pearson correlation coefficient (r) and determination regression coefficient (R2). As a result, the ANFIS-PSO algorithm represented the most accurate prediction of SP demand with RMSE = 0.0633, r = 0.9387 and R2 = 0.9871 in the testing phase.