Masonry buildings are very popular all over the world, and generally, they are assemblages of masonry units and mortar. However, they are prone to damage and even collapse due to the characteristics of masonry structures. The damages are mainly caused by natural disasters (e.g., flooding, earthquake, and landslide) or human activities (e.g., fire, vehicular impact, and insufficient maintenance). In order to assess the damage to masonry buildings, many approaches are commonly employed, such as on-site investigation, lab testing and experiments, and numerical simulations. In addition, retrofitting is always required for these damaged buildings, and resilience can be obtained to some extent by relying on different strengthening strategies. This article presents a state-of-the-art review of the current research on the multi-hazard assessment of masonry buildings, with a focus on three aspects, i.e., (1) natural and anthropic damages to masonry buildings; (2) applicability and reliability of analysis methods; and (3) strengthening technologies. A rapid and beneficial understanding is expected on the damages, analysis, and protection of ancient and modern masonry buildings.