Within the 2019–2021 research agreement between the Civil Protection Department (DPC) and the Network of University Laboratories for Earthquake Engineering (ReLUIS), the work package WP4 “Seismic Risk Maps—MARS” is specifically devoted to update the 2018 release of the Italian National Seismic Risk Assessment. To this end, the previously considered models of hazard, exposure and vulnerability will be critically reviewed and updated by taking advantage also from the results deriving from other WPs of the DPC-ReLUIS research project. In the present paper some of the most relevant aspects that are being introduced in the development of the new Italian risk maps have been described and shortly analysed. First, a significant upgrade of the vulnerability model implemented in the new version of the platform used for risk calculation (IRMA) is proposed, where reference to the six EMS-98 classes is made also considering regional vulnerability features. Further, empirical data from observed real damage are integrated with results from numerical simulations (mechanical approach), in particular for reinforced concrete buildings. Finally, some special construction types such as schools, churches and bridges are included in order to provide a more comprehensive view of the national risk.