This study investigates the blast effect on hoop stresses and displacements created on the wall of over-ground cylindrical reinforced concrete water tanks and the effect of blast waves, fluid surface motion, and the surface tension of water due to water-structure interaction using ABAQUS software. Three water tanks with heights of 4, 6, and 8 m and a fixed radius of 3 m were used for simulation, each of which was filled with 0, 25, 50, 75, and 100% water from the depth of the tank. The results revealed that the above parameters affect the water tank structure's dynamic response so that the surface tension of water is higher in water tanks with 50% water filling. Also, increasing the water filling percentage, the hardness of the water tank increased and decreased the tank wall displacement by 31.25% for a filled water tank compared to an empty water tank. The results illustratd that the water tank wall's hoop stresses were affected by blast waves from the outside and water tension from the inside, so that the water tension in the water tank caused an approximate 20 MPa increase in the hoop stresses on the wall.