The Western Gulf of Corinth (WGoC) exhibits significant seismicity patterns, combining intense microseismic background activity with both seismic swarms and short-lived aftershock sequences. Herein, we present a catalogue of ~9000 events, derived by manual analysis and double-difference relocation, for the seismicity of the WGoC during 2013–2014. The high spatial resolution of the hypocentral distribution permitted the delineation of the activated structures and their relation to major mapped faults on the surface. The spatiotemporal analysis of seismicity revealed a 32-km-long earthquake migration pattern, related to pore-pressure diffusion, triggering moderate mainshock-aftershock sequences, as fluids propagated eastwards in the course of ~15 months. The anisotropic properties of the upper crust were examined through automatic shear-wave splitting (SWS) analysis, with over 2000 SWS measurements at local stations. An average fast shear-wave polarization direction of N98.8° E ± 2.8° was determined, consistent with the direction of the maximum horizontal regional stress. Temporal variations of normalized time-delays between fast and slow shear-waves imply alterations in the level of stress or microcrack fluid saturation during the long-lasting pore-pressure diffusion episode, particularly before major events. The present study provides novel insights regarding seismicity patterns, active fault structures, anisotropic properties of the upper crust and triggering mechanisms of seismicity in the WGoC.