Taking into account recent studies on the tsunamigenic potential of strike-slip faults, it is concluded that there is a need to reassess their near-source tsunami hazard and risk. One of the areas which needs reassessment is Western Greece, especially the Ionian Islands and the western coastal Peloponnese, where major seismogenic strike-slip structures occur. In this context, an extensive review of the available literature is conducted, including not only earthquake and tsunami catalogues but also tsunamis’ imprints on the stratigraphic record. It is concluded that the Ionian Islands and the western Peloponnese have a rich history of tsunamis since 6000 BC, revealing that they are subjected to high tsunami hazard. In addition to the teletsunami effects of distant earthquakes, there are also local tsunamis with smaller physical quantities and slighter coastal impact that are attributed mainly to local offshore faults and earthquake-triggered landslides. The fact that no destructive local tsunamis have been detected so far does not exclude the possibility of future triggering. In order to identify areas susceptible to future tsunami impact, we extract tsunami quantities and coastal impact data from available sources and we apply the Integrated Tsunami Intensity Scale 2012 (ITIS-2012) for all the events with available and adequate information. The highly susceptible areas comprise straits, funnel-shaped bays and extensive coastal areas exposed to major strike-slip seismogenic sources in the Ionian Sea and the western Hellenic Trench. Based on the aforementioned information, the inclusion of the Ionian Sea in the tsunamigenic zones of Greece is strongly recommended.