The origin of mid-ocean ridge segmentation-the systematic along-axis variation in tectonic and magmatic processesremains controversial. It is commonly assumed that mantle flow is a passive response to plate divergence and that between transform faults magma supply controls segmentation. Using seismic tomography, we constrain the geometry of mantle flow and the distribution of mantle melt beneath the intermediate-spreading Endeavour segment of the Juan de Fuca Ridge. Our results, in combination with prior studies, establish a systematic skew between the mantle-divergence and plate-spreading directions. In all three cases studied, mantle divergence is advanced with respect to recent changes in the plate-spreading direction and the extent to which the flow field is advanced increases with decreasing spreading rate. Furthermore, seismic images show that large-o set, non-transform discontinuities are regions of enhanced mantle melt retention. We propose that oblique mantle flow beneath mid-ocean ridges is a driving force for the reorientation of spreading segments and the formation of ridge-axis discontinuities. The resulting tectonic discontinuities decrease the e ciency of upward melt transport, thus defining segment-scale variations in magmatic processes. We predict that across spreading rates mid-ocean ridge segmentation is controlled by evolving patterns in asthenospheric flow and the dynamics of lithospheric rifting.S ince the discovery that Earth's mid-ocean ridge system is divided into segments 1-3 a wealth of observations have shown that there are systematic, along-axis variations in tectonic and magmatic processes 2,4-6 . Between transform faults, the boundaries of ridge segments are defined by long-lived, non-transform tectonic offsets or second-order ridge crest discontinuities 2,3 ( Fig. 1) that often occur at axial depth maxima and that migrate along the plate boundary. These second-order discontinuities include overlapping spreading centres (OSCs) at fast-and intermediate-spreading rates, and oblique shear zones at slow-spreading rates. The origin of non-transform tectonic offsets and their relations to segment-scale magmatic processes remains actively debated 1,2,5-9 .The prevailing hypothesis for segmentation of spreading centres attributes second-order offsets to variations in magma supply from the upwelling mantle. In this view, segment centres overlie sites of increased melt supply and magma is redistributed along axis at crustal or mantle depths toward magma-starved segment ends 1,2,8,10 . Alternatively, competing hypotheses suggest that changes in the plate-spreading direction are related to the formation of tectonic offsets 7 and to a misalignment between sub-ridge mantle and crustal processes 9 . Here, we seismically image the geometry of mantle flow and the distribution of shallow mantle melt beneath the intermediate-spreading Endeavour segment of the Juan de Fuca Ridge (JdFR). We synthesize our results with observations from other spreading environments to identify the mechanisms responsible ...