Seizure Admissions to a City Hospital: The Role of Alcohol

Earnest, Michael P.; Yarnell, Philip R.

doi:10.1111/j.1528-1157.1976.tb04450.x

Cited by 91 publications

(37 citation statements)

References 14 publications

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“…The prevalence of alcohol use disorder was lower compared with the study conducted on admitted epileptic patients in United States of America (41%) 23. This variation might be due to cultural acceptance of drinking alcohol, accessibility of alcohol containing beverages, and severity of illness.…”

Section: Discussionmentioning

confidence: 55%

Prevalence of alcohol use disorders and associated factors among people with epilepsy attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Waja

Ebrahim

Yohannis

et al. 2016

NDT

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IntroductionAlcohol use disorders represent one of the leading causes of preventable death, illness, and injury in many societies throughout the world. Heavy alcohol consumption has multiple negative consequences for people with epilepsy such as precipitation of seizure, exacerbation of seizure, poor seizure control, increased side effects of antiepileptic drugs, noncompliance to antiepileptic drugs, alcohol withdrawal seizures, long-term hospital admission, status epilepticus, sudden unexpected death, and premature mortality.MethodsAn institution-based cross sectional study was conducted from April 15, 2014 to May 15, 2014 with the aim of assessing prevalence of alcohol use disorders and associated factors among people with epilepsy attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia. A total of 413 randomly selected epileptic patients were included in this study. Data were structured using the 10-item Alcohol Use Disorders Identification questionnaire. Data were analyzed using SPSS Version 20. Bivariate and multivariate logistic regression analyses were performed to study the association, and variables with P-value <0.05 were considered as having a statistically significant association at 95% confidence interval.ResultsA total of 423 study participants were selected, of whom 413 completely filled the questionnaire making the response rate 97.6%. The mean age of the respondents was 31.9 years with standard deviation of ±10.97, and 248 (60%) were males. The prevalence of alcohol use disorder was 17.4%. Educational status (grade 9–12) (adjusted odds ratio [AOR] =3.25, [1.21, 8.69]), not living with family members (AOR =1.89, [1.06, 3.39]), availability of house (AOR =2.04, [1.10, 3.78]), taking carbamazepine (AOR =2.38, [1.13, 5.01]), and drinking alcohol to find relief from stress (AOR =4.28, [1.89, 9.67]) were significantly associated with alcohol use disorder among people with epilepsy.Conclusion and recommendationThe findings of this study revealed that the prevalence of alcohol use disorder among people with epilepsy was high. Routine screening of epileptic patients with the Alcohol Use Disorders Identification Test is recommended.

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Section: Discussionmentioning

confidence: 55%

Prevalence of alcohol use disorders and associated factors among people with epilepsy attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Waja

Ebrahim

Yohannis

et al. 2016

NDT

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“…Alcohol-related seizures are a common form of acute non-genetic seizure,4 accounting for about 41–49% of all ER acute seizure problems 1 11. Furthermore, seizures are known to be provoked by long-term heavy drinking12 and are frequently associated with alcohol dependence 13.…”

Section: Discussionmentioning

confidence: 99%

Predictors of new-onset seizures: a 10-year follow-up of head trauma subjects with and without traumatic brain injury

Vaaramo

Puljula

Tetri

et al. 2013

Journal of Neurology, Neurosurgery & Psychiatry

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Background It is not known whether alcohol-related head trauma predicts the new-onset seizures, particularly alcohol-related seizures. Objective We investigated risk factors for new-onset seizures in a cohort of 739 head trauma subjects. Methods All subjects with head trauma attending Oulu University Hospital during 1999, including children and very old people but excluding persons with previous seizures and/or neurological diseases, were enrolled and followed up until the end of 2009. The Finnish National Hospital Discharge Register was used to identify all visits due to seizures during the 10-year follow-up. Dates of death were obtained from the official Cause-of-Death Statistics. Cox proportional hazard regression models and Kaplan-Meier survival curves were used to identify predictors of new-onset seizures. Results New-onset seizures were observed in 42 out of the 739 subjects (5.7%). An alcohol-related index injury (adjusted HR 2.50, 95% CI 1.30 to 4.82, p=0.006), moderate-to-severe traumatic brain injury (TBI) as the index trauma (3.13, 1.46 to 6.71, p=0.003) and preceding psychiatric disease (3.23, 1.23 to 9.21, p=0.028) were significant predictors of new-onset seizures during the follow-up after adjustment for age and sex. An alcohol-related index injury was the only independent predictor of the occurrence of an alcoholrelated new-onset seizure (adjusted HR 12.13, 95% CI 2.70 to 54.50, p=0.001), and these seizures (n=19) developed more frequently among subjects without (n=14) than with (n=5) TBI. Conclusions We conclude that alcohol-related head trauma predicts new-onset seizures, particularly alcoholrelated seizures. A brief intervention is needed in order to prevent the development of alcohol-related seizures.

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“…According to Victor and Brausch in their study, 88% of seizures were related to alcohol withdrawal alone. [2] In studies by Earnest and Yarnell[10] and Hillbom[11] alcohol withdrawal accounted for 59% and 31% of seizures respectively. In a recent study from India only 28% of seizures could be confidently attributed to alcohol withdrawal.…”

Section: Discussionmentioning

confidence: 99%

Clinical profile of patients with nascent alcohol related seizures

Sandeep

Cherian

Iype

et al. 2013

Ann Indian Acad Neurol

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Aim:The aim of this study is to characterize the clinical profile of patients with alcohol related seizures (ARS) and to identify the prevalence of idiopathic generalized epilepsy (IGE) in the same.Materials and Methods:100 consecutive male patients presenting to a tertiary care center in South India with new onset ARS were analyzed with alcohol use disorders identification test (AUDIT) score. All underwent 19 channel digital scalp electroencephalography (EEG) and at least computed tomography (CT) scan.Results:A total of 27 patients (27%) who had cortical atrophy on CT had a mean duration of alcohol intake of 23.62 years compared with 14.55 years in patients with no cortical atrophy (P < 0.001). Twenty-two patients (22%) had clustering in the current episode of whom 18 had cortical atrophy. Nearly, 88% patients had generalized tonic clonic seizures while 12% who had partial seizures underwent magnetic resonance imaging (MRI), which identified frontal focal cortical dysplasia in one. Mean lifetime duration of alcohol intake in patients presenting with seizures within 6 hours (6H-gp) of intake of alcohol was significantly lower (P = 0.029). One patient in the 6H-gp with no withdrawal symptoms had EEG evidence for IGE and had a lower AUDIT score compared with the rest.Conclusion:CT evidence of cortical atrophy is related to the duration of alcohol intake and portends an increased risk for clustering. Partial seizures can be a presenting feature of ARS and those patients may benefit from MRI to identify underlying symptomatic localization related epilepsy (8.3% of partial seizures). IGE is more likely in patients presenting with ARS within first 6 hours especially if they do not have alcohol withdrawal symptoms and scalp EEG is helpful to identify this small subgroup (~1%) who may require long-term anti-epileptic medication.

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Seizure Admissions to a City Hospital: The Role of Alcohol

Cited by 91 publications

References 14 publications

Prevalence of alcohol use disorders and associated factors among people with epilepsy attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Prevalence of alcohol use disorders and associated factors among people with epilepsy attending Amanuel Mental Specialized Hospital, Addis Ababa, Ethiopia

Predictors of new-onset seizures: a 10-year follow-up of head trauma subjects with and without traumatic brain injury

Clinical profile of patients with nascent alcohol related seizures

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