Seizure and radiological outcomes in children with solitary cysticercous granulomas with and without albendazole therapy: A retrospective case record analysis

Gulati, Sheffali; Jain, Puneet; Sachan, Deepak; Chakrabarty, Biswaroop; Kumar, Atin; Pandey, Ravindra Mohan; Gupta, Arun Kumar

doi:10.1016/j.eplepsyres.2014.04.013

Cited by 13 publications

(9 citation statements)

References 36 publications

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“…Previous studies that looked at the relationship among ALB, cyst phase, and seizure outcomes were all conducted among individuals with SCG. 14,15,29,30 Those studies suggest that although ALB hastens resolution of SCGs, it does not seem to alter the long-term seizure outcome. In contrast to previous studies that followed individual NC cyst evolution in SCG, our study also included participants with multiple cysts.…”

Section: Discussionmentioning

confidence: 96%

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Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis

et al. 2019

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Objective To develop a causal model for the occurrence of neurocysticercosis (NC)‐related seizures and test hypotheses generated from the model. Methods We used data from a randomized controlled trial comparing albendazole with placebo among patients newly diagnosed with NC. Based on our causal model, we explored the associations among albendazole treatment, NC cyst evolution, and seizure outcomes over 24 months of follow‐up using generalized linear mixed effect models. Results We included 153 participants, of whom 51% received albendazole. The association between seizure outcomes and treatment over time demonstrated lack of linearity and heterogeneity, requiring the inclusion of time‐treatment interaction terms for valid modeling. Participants in the albendazole group had fewer seizures overall and of partial onset at all time points compared with the placebo group, but the difference increased over the first few months following treatment, then decreased over time. Generalized seizures exhibited a more complex association; those in the albendazole group had fewer seizures compared with those in the placebo group for the first few months after treatment, and then the association reversed and those in the placebo arm had fewer seizures. Adjusting for the number of NC cysts in each phase resulted in an attenuation of the strength of association between albendazole and seizure outcomes, consistent with mediation. Among participants in whom all cysts had disappeared (n = 21), none continued to have seizures. Significance Albendazole treatment is associated with a possible reduction in focal seizures in the short term (3‐6 months), perhaps by hastening the resolution of the cysts. However, the effect is not discernible over the long term, because most cysts either calcify or resolve completely, regardless of whether treated with albendazole. The stage of evolution of the cysticercus is an important consideration in the evaluation of albendazole effect on seizure outcome.

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Section: Discussionmentioning

confidence: 96%

“…Previous studies that looked at the relationship among ALB, cyst phase, and seizure outcomes were all conducted among individuals with SCG . Those studies suggest that although ALB hastens resolution of SCGs, it does not seem to alter the long‐term seizure outcome.…”

Section: Discussionmentioning

confidence: 99%

Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis

et al. 2019

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“…Calcification in NCC is a common long-term outcome with observed rates of calcification in pediatric NCC varying widely from 6.2% to as high as 60% [24]. Interestingly, cysticidal therapy was found to have no significant effect in the calcification of solitary parenchymal NCC [25, 26].…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, cysticidal therapy was found to have no significant effect in the calcification of solitary parenchymal NCC [25, 26]. A retrospective analysis of solitary parenchymal NCC from India [24] reported that the risk of breakthrough seizures was significantly higher in calcified lesions on follow-up scan when compared to normal scans or persisting lesions. The same has been echoed in another prospective study involving both children and adults [27].…”

Section: Discussionmentioning

confidence: 99%

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Prevalence, Response to Cysticidal Therapy, and Risk Factors for Persistent Seizure in Indian Children with Neurocysticercosis

Kumar

Mandal

Sinha

et al. 2017

International Journal of Pediatrics

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Background. Neurocysticercosis (NCC) is the commonest cause of childhood acquired epilepsy in developing countries. The use of cysticidal therapy in NCC, except “single lesion NCC,” is still debated in view of its doubtful usefulness and potential adverse effects. Methods. Children presenting with first episode of seizure or acute focal neurological deficit without fever were screened for NCC and received appropriate therapy (followup done for 1 year to look for the response and side effects). Results. The prevalence of NCC was 4.5%. Most common presenting feature was generalized seizure and commonest imaging finding was single small enhancing lesion in the parietal lobe. Abnormal EEG and CSF abnormalities were found in almost half of the children. The response to therapy was very good with infrequent recurrence of seizure and adverse effects of therapy were encountered rarely. No risk factors for persistent seizure could be identified. Conclusion. Present study shows that the response to cysticidal therapy is very good in NCC as seizure recurrence was observed in only 5%, 4.2%, and 4.2% of cases at 3-month, 6-month, and 1-year followup. Adverse effects of therapy were observed in 20% of cases during therapy but they were mild and self-limiting.

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Radiological Outcome of Neurocysticercosis in Children Six Months After Diagnosis — A Single Center Study

2023

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Seizure and radiological outcomes in children with solitary cysticercous granulomas with and without albendazole therapy: A retrospective case record analysis

Cited by 13 publications

References 36 publications

Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis

Exploring the complex associations over time among albendazole treatment, cyst evolution, and seizure outcomes in neurocysticercosis

Prevalence, Response to Cysticidal Therapy, and Risk Factors for Persistent Seizure in Indian Children with Neurocysticercosis

Radiological Outcome of Neurocysticercosis in Children Six Months After Diagnosis — A Single Center Study

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