Seizure Associated with Olanzapine

Lee, Jerry; Crismon, M. Lynn; Dorson, Peter G.

doi:10.1345/aph.17385

Cited by 45 publications

(21 citation statements)

References 5 publications

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“…Recently, Lee et al reported the case of a 31-year-old woman who experienced seizure activity when switched from haloperidol to olanzapine treatment (Lee et al 1999). Several risk factors were present in this patient, including preexisting seizure disorder and concurrent pharmacotherapy (Lee et al 1999). In connection with the anecdotal observation of seizures under olanzapine treatment, our findings make EEG monitoring seem advisable in patients taking higher doses of olanzapine and in those with risk factors.…”

Section: Resultsmentioning

confidence: 58%

“…However, risk factors important in clinical routine (concomitant medication, neurological disease) are often excluded from controlled studies. Recently, Lee et al reported the case of a 31-year-old woman who experienced seizure activity when switched from haloperidol to olanzapine treatment (Lee et al 1999). Several risk factors were present in this patient, including preexisting seizure disorder and concurrent pharmacotherapy (Lee et al 1999).…”

Section: Resultsmentioning

confidence: 91%

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Electroencephalogram alterations during treatment with olanzapine

et al. 2000

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Section: Resultsmentioning

confidence: 58%

Section: Resultsmentioning

confidence: 91%

Electroencephalogram alterations during treatment with olanzapine

et al. 2000

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“…In other reports it is more difficult to establish the main precipitating factor because patients were receiving simultaneously olanzapine and other potentially proconvulsant drugs when seizures appeared. [8][9][10] There is one dramatic case that ended in fatal status epilepticus, 11 but in the remaining reports seizure activity could be controlled either by olanzapine discontinuation or by concurrent antiepileptic drugs.…”

Section: Discussionmentioning

confidence: 99%

Olanzapine-Induced Myoclonic Status

Camacho¹,

García-Navarro²,

Martínez³

et al. 2005

Clinical Neuropharmacology

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Olanzapine-related seizures have rarely been reported despite its proconvulsant risk. This is the first description of myoclonic status induced by this antipsychotic. A 54-year-old woman with probable Alzheimer disease developed continuous myoclonic jerks just after adding olanzapine for neuropsychiatric symptoms. She was already receiving citalopram and donepezil at low doses. Jerks coincided with spikes and polyspike/wave complexes on EEG. Olanzapine was immediately suspended and the seizures subsided. A control EEG showed no paroxysmal discharges. Several months later she was given haloperidol and she remained seizure free. Olanzapine shares some pharmacologic similarities with clozapine, a neuroleptic with a high risk of dose-dependent seizures. This adverse effect should be taken into account, and olanzapine should be used with caution if concomitant circumstances could decrease the seizure threshold.

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“…However, chronic administration of APs is known to alter the regional density of several neurotransmitter receptors in the central nervous system, including those for dopamine, serotonin, acetylcholine, histamine, and glutamate, that may contribute to the observed proconvulsant effects of some antipsychotics [42,53,54]. These changes, in particular upregulation of dopamine receptors, have been suggested as the basis for some of the adverse effects that occur with long-term antipsychotic therapy [55].…”

Section: General Considerations On the Effect Of Aps On Seizuresmentioning

confidence: 99%

Comparative Analysis of the Treatment of Chronic Antipsychotic Drugs on Epileptic Susceptibility in Genetically Epilepsy-prone Rats

et al. 2015

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Antipsychotic drugs (APs) are of great benefit in several psychiatric disorders, but they can be associated with various adverse effects, including seizures. To investigate the effects of chronic antipsychotic treatment on seizure susceptibility in genetically epilepsy-prone rats, some APs were administered for 7 weeks, and seizure susceptibility (audiogenic seizures) was evaluated once a week during treatment and for 5 weeks after drug withdrawal. Furthermore, acute and subchronic (5-day treatment) effects were also measured. Rats received haloperidol (0.2-1.0 mg/kg), clozapine (1-5 mg/kg), risperidone (0.03-0.50 mg/kg), quetiapine (2-10 mg/kg), aripriprazole (0.2-1.0 mg/kg), and olanzapine (0.13-0.66 mg/kg), and tested according to treatment duration. Acute administration of APs had no effect on seizures, whereas, after regular treatment, aripiprazole reduced seizure severity; haloperidol had no effects and all other APs increased seizure severity. In chronically treated rats, clozapine showed the most marked proconvulsant effects, followed by risperidone and olanzapine. Quetiapine and haloperidol had only modest effects, and aripiprazole was anticonvulsant. Finally, the proconvulsant effects lasted at least 2-3 weeks after treatment suspension; for aripiprazole, a proconvulsant rebound effect was observed. Taken together, these results indicate and confirm that APs might have the potential to increase the severity of audiogenic seizures but that aripiprazole may exert anticonvulsant effects. The use of APs in patients, particularly in patients with epilepsy, should be monitored for seizure occurrence, including during the time after cessation of therapy. Further studies will determine whether aripiprazole really has a potential as an anticonvulsant drug and might also be clinically relevant for epileptic patients with psychiatric comorbidities.

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Seizure Associated with Olanzapine

Cited by 45 publications

References 5 publications

Electroencephalogram alterations during treatment with olanzapine

Electroencephalogram alterations during treatment with olanzapine

Olanzapine-Induced Myoclonic Status

Comparative Analysis of the Treatment of Chronic Antipsychotic Drugs on Epileptic Susceptibility in Genetically Epilepsy-prone Rats

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