“…The National General Practice Study of Epilepsy (NG-PSE), a community-based study in the United Kingdom, saw the first case of SUDEP after 11,000 person-years of follow-up (Lhatoo and Sander 2001), and the results of the Medical Research Council Antiepileptic Drug Withdrawal Study showed that SUDEP is a rare event among patients with epilepsy in remission (1991). Information concerning risk factors for SUDEP is conflicting, but potential risk factors include: early adulthood, early onset of epilepsy (Nilsson et al 1999), long duration of epilepsy (Walczak et al 2001), uncontrolled seizures (mainly in those with TLE) (Walczak et al 2001, Sperling et al 1999, high seizure frequency (Walczak et al 2001, Langan et al 2005, certain seizure types (Walczak et al 2001, Kloster andEngelskjon 1999), higher numbers of AED (Nilsson et al 1999, Walczak et al 2001) and winter temperatures (Scorza et al 2007). Additionally, potential pathomechanisms for SUDEP are unknown, but it is very probable that cardiac arrhythmias during and between seizures, electrolyte disturbances, arrhythmogenic drugs or transmission of epileptic activity to the heart via the autonomic nervous system potentially play a role for SUDEP (Stollberger and Finsterer 2004).…”