Seizure-outcome after surgery of low-grade epilepsy associated neuro-epithelial tumors

Mehrotra, Anant; Singh, Sanjay; Kanjilal, Soumen; Pal, Lily; Paliwal, Vimal Kumar; Sardhara, Jayesh; Behari, Sanjay

doi:10.23736/s0390-5616.20.05144-9

Cited by 3 publications

(2 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A previous article from our center analyzed postsurgical 12-month seizure outcomes and neuropsychological outcomes in a partially overlapping patient population that underwent temporal lobe surgery ( 31 ). The present study aligns with previous studies, confirming that a complete lesion resection is an important prognostic factor which influences seizure control after surgery ( 14 , 16 , 32–37 ). This effect is likely more pronounced when taking into account that only patients with at least a 12-month FU were included in this study, and several patients who did not achieve satisfactory outcomes after the first surgery also underwent a second surgery, however, notably shorter than the 12-month FU, leading to their exclusion from the primary evaluation.…”

Section: Discussionsupporting

confidence: 92%

“…A lower age at surgery and a shorter epilepsy duration were identified as positive predictors for good postsurgical outcomes in patients with GG ( 15 , 37 ), in LEATs ( 32 , 34 ), and in pediatric patients with temporomesial GG and DNET ( 39 ), whereas short epilepsy duration was found to be a good prognostic factor in GG ( 16 , 33 ). In our series, however, we were unable to find convincing associations between age at surgery, epilepsy duration and postsurgical outcomes.…”

Section: Discussionmentioning

confidence: 94%

See 1 more Smart Citation

Long-term seizure outcome after epilepsy surgery of neuroglial tumors

Rácz,

Müller,

Becker

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

PurposeNeuroglial tumors are frequently associated with pharmacorefractory epilepsies. However, comprehensive knowledge about long-term outcomes after epilepsy surgery and the main prognostic factors for outcome is still limited. We sought to evaluate long-term outcomes and potential influencing factors in a large cohort of patients who underwent surgery for neuroglial tumors in a single-center setting.MethodsThe study analyzed the outcomes of 107 patients who underwent epilepsy surgery for neuroglial tumors between 2001 and 2020 at the Department of Epileptology, University Hospital Bonn, in Germany. The outcomes were evaluated using Engel classification. Differences in outcome related to potential prognostic factors were examined using the Chi2-test, Fisher’s exact test and sign test. Additionally, stepwise logistic regression analysis was employed to identify independent prognostic factors.ResultsComplete seizure freedom (Engel Class IA) was achieved in 75% of the operated patients at 12 months, and 56% at the last follow-up visit (70.4 ± 6.2 months, median: 40 months). Completeness of resection was a crucial factor for both 12-month follow-up outcomes and the longest available outcomes, whereas lobar tumor localization, histology (ganglioglioma vs. dysembryoplastic neuroepithelial tumor), history of bilateral tonic–clonic seizures prior to surgery, invasive diagnostics, side of surgery (dominant vs. non-dominant hemisphere), age at epilepsy onset, age at surgery, and epilepsy duration did not consistently impact postsurgical outcomes. Among temporal lobe surgeries, patients who underwent lesionectomy and lesionectomy, including hippocampal resection, demonstrated similar outcomes.ConclusionNeuroglial tumors present as excellent surgical substrates in treating structural epilepsy. To achieve an optimal postsurgical outcome, a complete lesion resection should be pursued whenever possible.

show abstract

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 94%

Long-term seizure outcome after epilepsy surgery of neuroglial tumors

Rácz,

Müller,

Becker

et al. 2024

Front. Neurol.

View full text Add to dashboard Cite

show abstract

IDH1 mutation predicts seizure occurrence and prognosis in lower-grade glioma adults

Tang,

Wang,

Dai

et al. 2024

Pathology - Research and Practice

View full text Add to dashboard Cite

A novel histopathological grading system for ganglioglioma

et al. 2021

View full text Add to dashboard Cite

Gangliogliomas are central nervous system tumors located in the temporal lobe of young patients, frequently associated with epilepsy. In this paper, we propose a grading system based solely on histopathological criteria. We reevaluated all cases of ganglioglioma, atypical ganglioglioma, and anaplastic ganglioglioma diagnosed between 2011 and 2020 in the Pathology Department of the Emergency Clinical Hospital Bagdasar-Arseni, based on the type of glial mitoses, the number of neuronal and glial mitoses, presence of necrosis, microvascular proliferation, eosinophilic granular bodies, hypercellularity, presence and disposition of inflammatory infiltrate and atypical pleomorphism. Based on the proposed grading system, a score of 0–4 corresponded to a benign ganglioglioma, 5–9 to an atypical ganglioglioma, and 10–18 to an anaplastic ganglioglioma. The survival rates were 90% for benign ganglioglioma, 71.43% for atypical ganglioglioma, and 62.54% for anaplastic ganglioglioma. One case of benign ganglioglioma underwent a malignant transformation into anaplastic ganglioglioma, and recurrences were noticed in 28.57% of atypical ganglioglioma cases and 30.7% of all anaplastic gangliogliomas. The presence of rare glial mitoses and hypercellularity was correlated with mortality in cases of atypical ganglioglioma. We believe this histopathological scoring system could be used as a three-tier system to identify atypical ganglioglioma cases that are bound to have an aggressive course of evolution and require close follow-up. The other option would be to convert it to a two-tier grading system that can separate low-grade gangliogliomas from high-grade ones. The latter category can encompass both atypical and anaplastic ganglioglioma due to the high mortality of both entities.

show abstract

Seizure-outcome after surgery of low-grade epilepsy associated neuro-epithelial tumors

Cited by 3 publications

References 36 publications

Long-term seizure outcome after epilepsy surgery of neuroglial tumors

Long-term seizure outcome after epilepsy surgery of neuroglial tumors

IDH1 mutation predicts seizure occurrence and prognosis in lower-grade glioma adults

A novel histopathological grading system for ganglioglioma

Contact Info

Product

Resources

About