Seizures and epilepsy and their relationship to autism spectrum disorders

Matson, Johnny L.; Neal, Daniene

doi:10.1016/j.rasd.2009.06.003

Cited by 39 publications

(24 citation statements)

References 79 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Vision and hearing impairments are also common relative to the general population (Deggouj & Elliot, 2005; Johansson, Gillberg, & Rastam, 2010; Roper, Arnold, & Monteiro, 2003; Vernon & Rhodes, 2009). Seizure disorders (Matson & Neal, 2009), gastrointestinal problems (Wang, Tancredi, & Thomas, 2011), and sleep problems (Kotagal & Broomall, 2012) are also observed at increased rates in individuals with autism. It is recommended that parents be asked about all other conditions at intake and that significant information about participant co-morbidities be available for reporting and analysis.…”

Section: Diagnosis and Definition Of Participantsmentioning

confidence: 99%

Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism

Webb

Bernier

Henderson

et al. 2013

J Autism Dev Disord

View full text Add to dashboard Cite

The EEG reflects the activation of large populations of neurons that act in synchrony and propagate to the scalp surface. This activity reflects both the brain’s background electrical activity and when the brain is being challenged by a task. Despite strong theoretical and methodological arguments for the use of EEG in understanding the neural correlates of autism, the practice of collecting, processing and evaluating EEG data is complex. Scientists should take into consideration both the nature of development in autism given the life-long, pervasive course of the disorder and the disability of altered or atypical social, communicative, and motor behaviors, all of which require accommodations to traditional EEG environments and paradigms. This paper presents guidelines for the recording, analyzing, and interpreting of EEG data with participants with autism. The goal is to articulate a set of scientific standards as well as methodological considerations that will increase the general field’s understanding of EEG methods, provide support for collaborative projects, and contribute to the evaluation of results and conclusions.

show abstract

Section: Diagnosis and Definition Of Participantsmentioning

confidence: 99%

Guidelines and Best Practices for Electrophysiological Data Collection, Analysis and Reporting in Autism

Webb

Bernier

Henderson

et al. 2013

J Autism Dev Disord

View full text Add to dashboard Cite

show abstract

“…By definition, these impairments are pervasive and affect multiple domains of health and functioning. In addition to these core symptom domains, behavioral co-morbidities are common and include symptom patterns indicative of attentiondeficit/hyperactivity disorder (ADHD), anxiety disorders, oppositional behavior, mood disorders, thought dysfunction/psychosis, severe irritability, and aggression (Lee and Ousley 2006;Zafeiriou et al 2007;LoVullo and Matson 2009;MacNeil et al 2009;Matson and Neal 2009;Souders et al 2009). A growing body of efficacy and effectiveness studies have demonstrated that many individuals with ASD benefit from medication treatment of associated symptoms and co-morbidities (Huffman et al 2011), either as a first-line treatment (McCracken et al 2002;Shea et al 2004;Marcus et al 2009;Owen et al 2009) or combined with behavior therapy Frazier et al 2010).…”

mentioning

confidence: 99%

Prevalence and Correlates of Psychotropic Medication Use in Adolescents with an Autism Spectrum Disorder with and without Caregiver-Reported Attention-Deficit/Hyperactivity Disorder

Frazier

Shattuck²,

Narendorf³

et al. 2011

Journal of Child and Adolescent Psychopharmacology

106

View full text Add to dashboard Cite

Background: Many youths with an autism spectrum disorder (ASD) benefit from psychotropic medication treatment of comorbid symptom patterns consistent with attention-deficit/hyperactivity disorder (ADHD). The lack of clear indications and algorithms to direct clinical practice has led to a very poor understanding of overall medication use for these youths. The present study examined the prevalence of psychotropic medication use compared across individuals with an ASD without a caregiver-reported ADHD diagnosis (ASD-only), ADHD without ASD (ADHD-only), and an ASD with co-morbid ADHD (ASD + ADHD). Correlates of medication use were also examined. Methods: Data on psychotropic medication from the first wave of the National Longitudinal Transition Study 2, a nationally representative study of adolescents ages 13-17 in special education, were used to compare the prevalence of medication use across the three groups, overall and by class. Separate logistic regression models were constructed for each group to examine the correlates of psychotropic medication use. Poisson regression models were used to examine correlates of the number of medications. Results: Youths with ASD + ADHD had the highest rates of use (58.2%), followed by youths with ADHD-only (49.0%) and youths with ASD-only (34.3%). Youths with an ASD, both ASD-only and ASD + ADHD, used medications across a variety of medication classes, whereas stimulants were dominant among youths with ADHD-only. African American youths with ASDonly and with ASD + ADHD were less likely to receive medication than white youths, whereas race was not associated with medication use in the ADHD-only group. Conclusions: Clearer practice parameters for ADHD have likely contributed to more consistency in treatment, whereas treatment for ASD reflects a trial and error approach based on associated symptom patterns. Additional studies examining the treatment of core and associated ASD symptoms are needed to guide pharmacologic treatment of these youths. Interventions targeting African American youths with ASD and the physicians who serve them are also warranted.

show abstract

“…A seizure is commonly understood as uncontrolled electrical activity in the brain, which may produce a physical convulsion, minor physical signs, changes in consciousness, thought disturbances, sensory disturbances, or a combination of symptoms. While the terms seizure disorder and epilepsy are generally used interchangeably, epilepsy is more formally defined as having two or more seizures within a set period of time, most often within 3 years, for which there is no other identifiable cause such as mass lesion, head trauma, infection, toxic exposure, or metabolic derangement (Matson & Neal, 2009).…”

Section: Terminologymentioning

confidence: 99%

“…It has been theorized that epilepsy with a late onset during adolescence is brought on by the hormonal fluctuations associated with puberty (Gillberg, 1991). One study of children with autism showed that seizure activity peaks between 3 and 10 years of age (Matson & Neal, 2009). Other studies, however, have suggested that epilepsy has two peaks in children with autism: one during infancy and another during adolescence (Olsson et al, 1988).…”

Section: Age Of Seizure Onsetmentioning

confidence: 99%

“…To date, there are scant empirical data related to the moderating or mediating effects of epilepsy and ASD on one another in relation to developmental course and outcomes. In general, children with comorbid or co-occurring ASD and seizures/epilepsy have lower IQ, lower adaptive behavior, more emotional problems, and evidence more frequent use of psychiatric medications (Matson & Neal, 2009). Also, a higher rate of seizure activity has been linked to decreased intellectual functioning (Matson & Neal, 2009), but is unclear how medications or other factors (e.g., other neurological factors) may be contributing to this suspected association.…”

Section: Developmental Coursementioning

confidence: 99%

See 1 more Smart Citation